The Study of the Effect of Alcoholic Extract of Triticum sativum, on the Skin Wound Healing in Diabetic Male Wistar Rats

Journal of Chemical Health Risks

مقاله 16، دوره 11، Special Issue: Bioactive Compounds: Their Role in the Prevention and Treatment of Diseases، دی 2021، صفحه 135-141   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.22034/jchr.2021.683740

نویسندگان

Asma Movaghar؛ Vida Hojati؛ Abdolhossein Shiravi^*

Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran

چکیده

Diabetes mellitus is one of the most common diseases in the body’s endocrine system. This disease is caused due to lack of cellular uptake of blood glucose due to a decrease of insulin secretion and insulin resistance in the body cells. Besides the development of diabetes, the more common underlying medical condition, such as foot deformities, foot ulcers, and infection, spreads. Wheat, with the scientific name “Triticum sativum”, is a multiple therapeutic effect, including amplifiers, healer of wounds, stimulating and antiseptic, decreasing blood sugar and pressure, which can be beneficial in balancing sugar and insulin in the blood. Therefore, in this study, the effect of this plant was investigated on skin wound healing in diabetic rats. 48 male rats under the name of Wistar race weighing 200 to 220 grams were categorized into 4 groups and each group has 12 rats in the four categories: control group (without diabetes and treatment), sham (diabetic, treatment with Eucerin), experimental group 1 (diabetic without treatment), and experimental group 2 (diabetic and treatment with Triticum sativum ointment). Some scars were created with a length of 3 cm on the skin of the dorsal lumbar region in the rats of each group, and daily wound healing on these rats was observed. The results indicate that experimental group 2, compared to the rest of the other groups, has the best effect on wound healing. Based on the results of this study, probably, the extract of Triticum sativum, due to anti-steroid and anti-inflammatory attributes, can lead to improvement and decrease the length of the wound in the animal, after 21 days.

کلیدواژه‌ها

Diabetes؛ Triticum sativum؛ Wound؛ Skin؛ Rat

مراجع

1. Nakamura U., Iwase M., Uchizono Y., Sonoki K., Sasaki N., Imoto H., Goto D., Iida M., 2006. Rapid intracellular acidification and cell death by H₂O₂ and alloxan in pancreatic ß cells. Free Radical Biology & Medicine. 40, 2047-2055.

2. Tripathi B.K., Srivastava A.K., 2006. Diabetes mellitus: complications and therapeutics. Med Sci Monit. 12, 130-47.

3. Smeltzer S.C., 2010. Brunner and Suddarth's Textbook of Medical-Surgical Nursing. 1st Edition, Lippincott Williams and Wilkins, Philadelphia, US. pp. 1113.

4. Xu K., Yu F.S.X., 2011. Impaired epithelial wound healing and EGFR signaling pathways in the corneas of diabetic rats. Invest. Ophthalmol Vis. Sci. 52, 3301-3308.

5. Lin Z.H., Tschang T., Liao K., Su C., Wu J., Ho M., 2016. Ar/O Argon-Based Round Atmospheric-Pressure Plasma Jet on Sterilizing Bacteria and Endospores. IEEE Trans. Plasma Sci. 1-8.

6. Martin P., 1997. Wound healing–aiming for perfect skin regeneration. Science. 276(5309), 75-81.

7. Juniantito V., Izawa T., Yamamoto E., Murai F., Kuwamura M., Yamate J., 2011. Heterogeneity of Macrophage Populations and Expression of Galectin-3 in Cutaneous Wound Healing in Rats. J Comp Pathol. 145, 378-389.

8. Juniantito V., Izawa T., Yuasa T., Ichikawa C., Yano R., Kuwamura M., Yamate J., 2013. Immunophenotypical characterization of macrophages in rat bleomycin-induced scleroderma. Vet Pathol. 50(1), 76-85.

9. Koh T.J.K., DiPietro L.A., 2013. Inflammation and wound healing: The Role of the Macrophage. 16, 19-25.

10. Bielefeld K.A., Amini-Nik S. Alman B.A., 2013. Cutaneous wound healing: Recruiting developmental pathways for regeneration. Cell Mol Life Sci. 70, 2059-2081.

11. Kurtz E.S., Wallo W., 2007. Colloidal oatmeal: history, chemistry and clinical properties. J Drugs Dermatol. 6, 167-70.

 

12. Zargari A., 2011. Medicinal plants. Tehran University Publications, Tehran, 8th edition. pp 4275. [In Persian]

13. Gürbüz I., Akyüz C., Yeşilada E., Şener B., 2000. Antiulcerogenic effect of Momordica  charantia L. fruits on various ulcer models in rats. J Ethnopharmacol.  71, 77-82.

14. Handa S.S., Chawla A.S., 1989.  Hypoglycemic plants- review. Fitotrapia. 60, 195-98.

15. Asuzu I.U., Onu O.U., 1990. Anti-ulcer activity of the ethanolic extract of Combretum dolichopetalum root. J Ethnopharmacology.  28, 27-32.

16. Boisnic S., 2005. Healing effect of spray containing Rhealba oat colloidal extract in an in vitro recons reconstitution model of skin. Tissue React. 27, 83-89.

17. Chevallier A., 2005. Encyclopedia of herbal medicine. New York, Dorling Kindersley. pp.336.

18. Kurtz E.S., Wallo W., 2007. Colloidal oatmeal: history, chemistry and clinical properties. J Drugs Dermatol.  6, 167-70

19. Goldsmith P.K., Fan G., Miller J.L., Rogers K.V., Spiegel A.M., 1997. Monoclonal antibodies against synthetic peptides corresponding to the extracellular domain of the human Ca²⁺ receptor: characterization and use in studying concanavalin A inhibition. Journal of Bone and Mineral Research. 12(11), 1780-1788.

20. Solomon M.P., Granick M.S., 1998. Bipedicle muscle flaps in sternal wound repair. Plastic and Reconstructive Surgery. 101(2), 356-360.

21. Sachin J., Neetesh J., Tiwari A., Balekar N., Jain D.K., 2009. Simple evaluation of wound healing activity of polyherbal formulation of roots of Ageratum conyzoides Linn. Asian J Res Chem. 2(2), 135-138.

22. Kumar B., Vijayakumar M., Govindarajan R., Pushpangadan P., 2007. Ethnopharmacological approaches to wound healing exploring medicinal plants of india. J Ethnopharmacol. 114 (2), 103-113.

23. Beutler E., Kelly B.M., 1963. The effect of sodium nitrate on red cell glutathione. Experentia.19, 96-97.

24. Dweck A.C., Cavin J.P., 2006. Andawali (Tinospora crispa): A review. Personal Care Magazine. 7, 33-39.