Synthesis and Characterization of 1-(2-Methyl-4-(4-methylbenzoyl)-7-thioxo-5-p-tolylpyrazolo[1,5-f]pyrimidin-1(7H)-yl)propan-2-one

Journal of Chemical Reactivity and Synthesis

دوره 9، شماره 3، آبان 2019، صفحه 52-57   

نوع مقاله: Research Article

نویسندگان

Zülbiye Kökbudak¹؛ Halime Güzin Aslan¹؛ Zeynep Çimen²؛ Senem Akkoç^{* 3}

¹Erciyes University, Faculty of Science

²Hacı Bayram Veli University, Ankara, Turkey

³Suleyman Demirel University, Faculty of Pharmacy

چکیده

Compounds containing pyrimidine ring attract researchers' attention due to their different properties. For example, Ishida et al. synthesized Cu(II) complexes having pyrimidine ring, and investigated their magnetic properties. By Wiśniewski et al., Ru(III), Rh(III), Pd(II) and Pt(II) metal complexes containing pyrimidine ring were designed and tested as in vitro against A549, LS-180 and MCF-7 cell lines for learning their cell proliferation activities. In the conducted study by Kökbudak et al., a series of various metal complexes were prepared from a Schiff base having pyrimidine core, and the cytotoxic activity properties of the complexes were screened against human lung cell line.
In this study, 1-amino-5-(4-methylbenzoyl)-4-(4-methylphenyl)pyrimidin-2(1H)-thione (1) was prepared in two steps by the reaction of furan-2,3-dione and acetophenon thiosemicarbazone. 1-(2-Methyl-4-(4-methylbenzoyl)-7-thioxo-5-p-tolylpyrazolo[1,5-f]pyrimidin-1(7H)-yl)propan-2-one (2) was synthesized from compound 1 with α-chloracetone. The structure of new compound 2 was verified by FT-IR, 1H NMR, 13C NMR and elemental analyses. The theoretical properties of compound 2 was also calculated using Gaussian 09 program.

کلیدواژه‌ها

Aminopyrimidine؛ α-chloracetone؛ pyrazolo[1؛ 5-f]pyrimidin