Potential of magnetite nanoparticles with biopolymers loaded with gentamicin drug for bone cancer treatment

Journal of Nanoanalysis

دوره 8، شماره 3، آذر 2021، صفحه 188-198   

نوع مقاله: Original Research Paper

شناسه دیجیتال (DOI): 10.22034/jna.2021.685869

نویسندگان

Ehsan Nassireslami¹؛ Mehdi Motififard²؛ Bahareh Kamyab Moghadas³؛ Zahra Hami⁴؛ Amir Jasemi³؛ Amin Lachiyani⁵؛ Reza Shokrani Foroushani⁵؛ Saeed Saber-Samandari⁶؛ Amirsalar Khandan^{* 7}

¹1 Toxicology Research Center, AJA University of Medical Sciences, Tehran; Iran 2 Department of Pharmacology and Toxicology, AJA University of Medical Sciences, Tehran, Iran

²Department of Orthopedic Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

³Department of Chemical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran

⁴Toxicology Research Center, AJA University of Medical Sciences, Tehran; Iran

⁵Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

⁶New Technologies Research Center, Amirkabir University of Technology, Tehran, Iran

⁷New Technology Research Center, Amirkabir University of Technology, Tehran, Iran

چکیده

Objective(s): Due to the natural bone microstructure, the design and fabrication of
porous ceramic scaffold nanocomposite materials coated with a thin layer of a natural
the polymer can provide an ideal scaffold for bone tissue engineering. This study aimed to
fabricate multi-component porous magnetic scaffolds by freeze-drying (FD) technique
using a gelatin polymer layer coated with a gentamicin drug.
Methods: Magnetic nanoparticles (MNPs) can be manipulated and controlled by
an external magnetic field gradient (EMFG) that is inherent in the magnetic field's
permeability within human tissues. In the present work, unlike the usual ceramic/
polymer composite scaffold, the ceramic components, and the magnet were placed
together in the reaction medium from the beginning, and bioceramics were replaced
in the composite polymer network and then coated with a drug-loaded polymer. To
evaluate the morphology of the magnetic scaffold, scanning electron microscopy
(SEM) was utilized to evaluate the microstructure and observe the porosity of the
porous tissue.
Results: After analyzing the SEM images, the porosity of the scaffolds was measured,
which was similar to the normal bone architecture. The addition of gentamicin to
the gelation was investigated to monitor the drug delivery reaction in the biological
environment. The magnetic properties of the sample were evaluated using the
hyperthermia test for 15 seconds at the adiabatic conditions. Also, the porosity value
increased from 55% to 78% with the addition of MNPs to the based matrix.
Conclusions: The results of this study showed that gentamicin-gelatin-coated on
porous ceramic-magnet composite scaffolds could be used in bone tissue engineering
and apply for treatment of bone tumors, because of their similarity to the bone
structure with good porosity.

کلیدواژه‌ها

Drug Delivery System؛ Magnetization؛ Magnetic Nanoparticles؛ Malignant Tumor