The effects of hyssop hydroalcoholic extract on the serum biochemical factors of rats

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

دوره 12، شماره 3، دی 2021، صفحه 23-29   

نوع مقاله: Original article

شناسه دیجیتال (DOI): 10.30495/medherb.2021.686161

نویسندگان

Pegah sadat Etminan¹؛ Mohsen Jafarian Dehkordi^{* 2}؛ Maryam Karimi Dehkordi³

¹D.V.M. Graduate, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

²Department of clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran;

³Department of clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

چکیده

Background & Aim: Investigating the effects of medicinal plants on the basal physiology of the body is one of the main topics in the application of medicinal plants. Hyssop (Hyssopus officinalis) or Zofa is one of most important medicinal plants in Iran with numerous therapeutic properties such as antibacterial, antifungal, anti-inflammatory, and analgesic effects. However, there is limited information on its effects on the basal physiology of the body. The aim of this study was to investigate the effects of hydroalcoholic extract of hyssop on liver and kidney activities in rats under normal physiological conditions.
Experimental: For this purpose, 32 male rats of the Wistar breed were used. The rats were allocated to one control group and three experimental groups. The experimental groups received the hydroalcoholic extract of Zufa at 150, 100 and 50 mg/kg concentration levels for 21 days. After the trial, blood samples were collected to measure liver and kidney health indices.
Results: The results showed that hyssop extract did not significantly affect cholesterol and ALT levels (P>0.05); while, significantly reduction in AST levels was observed. Consumption of hyssop extract at the concentration of 150 mg/kg b.w significantly increased GGT level (P<0.05); however, a significant decrease (P<0.05) was observed in creatinine and BUN parameters at the concentration level of 100 mg/kg. Consumption of hyssop extract did not affect HDL levels, whereas, at the concentration level of 150 mg/kg, LDL levels were significantly decreased (P<0.05). Moreover, a decreasing trend in glucose and triglyceride levels was observed with the consumption of hyssop extract
Recommended applications/industries: Generally, Zufa extract at 100 mg/kg concentration level can effectively lower blood sugar without any negative effects on the liver and kidney health.

کلیدواژه‌ها

Hyssopus officinalis؛ Zufa؛ kidney؛ Liver؛ rat

مراجع

Akbarizadeh, N., Khatibjoo, A., Varmaghani, S., Jaefari, H. and Shokri, A.N. 2020. Effect of Hyssopus officinalis, Virginiamycine and Aspirine on growth performance, immunity, and ascites indices of broiler chicken under cold stress. Journal of Animal Production, 22(2): 289-299. [In Persian].

Alinezhad, H., Azimi, R., Zare, M., Ebrahimzadeh, M.A., Eslami, S., Nabavi, S.F. and Nabavi, S.M. 2013. Antioxidant and antihemolytic activities of ethanolic extract of flowers, leaves, and stems of Hyssopus officinalis L. Var. angustifolius. International Journal of Food Properties, 16(5): 1169-1178.

Alizadeh, A., Khoshkhui, M., Javidnia, K., Firuzi, O., Tafazoli, E. and Khalighi, A. 2010. Effects of fertilizer on yield, essential oil composition, total phenolic content and antioxidant activity in Satureja

 

 

    hortensis L.(Lamiaceae) cultivated in Iran. Journal of Medicinal Plants Research, 4(1): 33-40.

AnandhBabu, P.V., Sabitha, K.E. and Shyamaladevi, C.S. 2006. Green tea extract impedes dyslipidaemia and development of cardiac dysfunction in streptozotocin‐diabetic rats. Clinical and Experimental Pharmacology and Physiology, 33(12): 1184-1189.

Bahmani, M., Zargaran, A. and Rafieian-Kopaei, M. 2014. Identification of medicinal plants of Urmia for treatment of gastrointestinal disorders. RevistaBrasileira de Farmacognosia, 24(4): 468-480.

Bakkali, F., Averbeck, S., Averbeck, D. and Idaomar, M. 2008. Biological effects of essential oils–a review. Food and Chemical Toxicology, 46(2): 446-475.

Bugayong, A.M., Cruz, P. and Padilla, P.I. 2019. Antibacterial Activity and Chemical Composition of Essential Oils from Leaves of Some Aromatic Plants of Philippines. Journal of Essential Oil Bearing Plants, 22(4): 932-946.

Chang, N., Luo, Z., Li, D. and Song, H. 2017. Indigenous uses and pharmacological activity of traditional medicinal plants in Mount Taibai, China. Evidence-Based Complementary and Alternative Medicine, 2017.

Dehghanzadeh, N., Ketabchi, S. and Alizadeh, A. 2012. Essential oil composition and antibacterial activity of Hyssopus officinalis L. grown in Iran. Asian Journal of Experimental Biological Sciences, 3(4): 767-771.

Dorman, H.D. and Deans, S.G. 2000. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. Journal of Applied Microbiology, 88(2): 308-316.

Eidi, A., Minaiee, T.D. And Hatami, M. 2009. Effect of olive leaves extract on Serum AST and ALT levels in ccl4-induced liver damage in rats. Biological Sciences (danish-izisti-iiran), 3(4): 1-7. [In Persian].

GhasemiPirbalouti, A., Taheri, M., Raiesi, M., Bahrami, H. and Abdizadeh, R. 2009. In vitro antifungal activity of plant extracts on Saprolegniaparasitica from cutaneous lesions of rainbow trout (Oncorhynchusmykiss) eggs. Journal of Food, Agriculture and Environment, 7(2): 94-96.

Hall, P. and Cash, J. 2012. What is the real function of the liver ‘function’tests?. The Ulster Medical Journal, 81(1): 30.

Hatipoğlu, G., Sökmen, M., Bektaş, E., Daferera, D., Sökmen, A., Demir, E. and Şahin, H. 2013. Automated and standard extraction of antioxidant phenolic compounds of Hyssopus officinalis L. ssp. angustifolius. Industrial Crops and Products, 43: 427-433.

Heydarian, E., Hajhosseini, R., Jafari, D.A. And Omidi, H. 2008. Effects of pistachio nut powder on rat liver phosphatidatephosphohydrolase and serum lipids and lipoproteins profile. Journal of Ilam University of Medical Sciences, 16(1): 47-55. [In Persian].

Jivad, N. and Rabiei, Z. 2014. A review study on medicinal plants used in the treatment of learning and memory impairments. Asian Pacific Journal of Tropical Biomedicine, 4(10): 780-789.

Lu, M., Battinelli, L., Daniele, C., Melchioni, C., Salvatore, G. and Mazzanti, G. 2002. Muscle relaxing activity of Hyssopus officinalis essential oil on isolated intestinal preparations. Plantamedica, 68(03): 213-216.

Lundstrom, K., Pham, H.T. and Dinh, L.D. 2017. Interaction of plant extracts with central nervous system receptors. Medicines, 4(1): 12.

Maroyi, A. and Semenya, S.S. 2019. Medicinal uses, phytochemistry and pharmacological properties of elaeodendron transvaalense. Nutrients, 11(3): 545.

Mazzanti, G., Battinelli, L. and Salvatore, G. 1998. Antimicrobial properties of the linalol‐rich essential oil of Hyssopus officinalis L. vardecumbens (Lamiaceae). Flavour and Fragrance Journal, 13(5): 289-294.

Modaresi, M., Mesripour., M., Ghobadipour, M. 2006. Effect of hydroalcoholicZingiber extract on creatinine and blood urea nitrogen (BUN) of mice. Journal of Shahrekord Uuniversity of Medical Sciences, 8(3): 48-53. [In Persian].

Mulabagal, V. and Tsay, H.S. 2004. Plant cell cultures-an alternative and efficient source for the production of biologically important secondary metabolites. International Journal of Applied Science and Engineering, 2(1): 29-48.

Nasirpour, M., Yavarmanesh, M., MohhamadiSani, A. and MohamdzadeMoghadam, M. 2014. Antibacterial effect of aqueous extract of Artemisia aucheri, Artemisia sieberi and Hyssopus officinalis L. on the food borne pathogenic bacteria. Journal of Food Science and Technology, 12(46): 53-64.

Pouraboli, I. and Ranjbar, B. 2014. The Effect of Daucuscarota ssp. sativum seeds extract on serum levels of Renal Function Indicators and liver function enzymes in type I diabetes Model. Journal of Sabzevar University of Medical Sciences, 21(3): 370-378. [In Persian].

Raissy, M., Keyhani, K., and Pirali, K. 2020. Comparison of the effects of geranium, lavender, and garlic extracts on Ichthyophthirius multifiliis in naturally infected Capoeta damascina. Journal of Animal Environment, 12 (4), 123-126. [In Persian].

Raissy, M. Ghafarifarsani, H., Hoseinifar, S.H., El-Haroun, E.H., Shahbazi, S., Van Doan, H. 2022. The effect of dietary combined herbs extracts (oak acorn, coriander, and common mallow) on growth, digestive enzymes, antioxidant and immune response, and resistance against Aeromonas hydrophila in common carp, Cyprinus carpio. Aquaculture, 546: 737287.

Rashidi, A.A., Mirhashemi, S.M., Taghizadeh, M. and Sarkhail, P. 2013. Iranian medicinal plants for diabetes mellitus: a systematic review. Pakistan Journal of Biological Sciences, 16(9): 401-411.

Saeb, M., Nazifi, S. andMirzaei, A. 2004. Effect of wild pistachio oil on blood serum fats and lipoproteins Female rabbits. Journal of Shahid Sadoughi University of Medical Sciences, 12(3): 42-52. [In Persian]

Sahoo, S. 2018. Medicinal uses of plants for nervous disorders. Advances in Complementary and Alternative Medicine, 3: 1-6.

Said-Al Ahl, H.A., Abbas, Z.K., Sabra, A.S. and Tkachenko, K.G. 2015. Essential oil composition of Hyssopus officinalis L. cultivated in Egypt. International Journal of Plant Science and Ecology, 1(2): 49-53.

Salehi, A. and Setorki, M. 2018. Analgesic and anti-inflammatory effects of ethanolic extract of Hyssopus officinalis in mice. Journal of Gorgan University of Medical Sciences, 20(2): 42-47. [In Persian].

Solar, A., Colarič, M., Usenik, V. and Stampar, F. 2006. Seasonal variations of selected flavonoids, phenolic acids and quinones in annual shoots of common walnut (Juglansregia L.). Plant Science, 170(3): 453-461.

Tangjitman, K., Wongsawad, C., Kamwong, K., Sukkho, T. and Trisonthi, C. 2015. Ethnomedicinal plants used for digestive system disorders by the Karen of northern Thailand. Journal of Ethnobiology and Ethnomedicine, 11(1): 27.

Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M. and Impicciatore, M. 2006. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sciences, 78(13): 1419-1432.