تعداد نشریات | 418 |
تعداد شمارهها | 9,987 |
تعداد مقالات | 83,493 |
تعداد مشاهده مقاله | 76,777,465 |
تعداد دریافت فایل اصل مقاله | 53,858,805 |
Evaluation of Antibacterial Effect of Zinc Oxide Nanoparticles Synthesized by Wet-chemically Method on Multidrug-resistant Uropathogenic Bacteria | ||
Journal of Nanoanalysis | ||
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 06 دی 1400 | ||
نوع مقاله: Original Research Paper | ||
شناسه دیجیتال (DOI): 10.22034/jna.2021.1930086.1255 | ||
نویسندگان | ||
Maryam Bagheri Mohammad Gholipour1؛ Monir Doudi* 2؛ Ali Mohammad Ahadi3؛ Gholam Reza Amiri4 | ||
1Department of Microbiology, Islamic Azad University, Falavarjan Branch, Falavarjan, Isfahan, Iran. | ||
2Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran | ||
3Department of Genetics, Shahrekord University, Shahrekord, Chaharmahal and Bakhtiari, Iran. | ||
4Department of Basic Sciences, Islamic Azad University, Falavarjan Branch, Falavarjan, Isfahan, Iran. | ||
چکیده | ||
Zinc oxide (ZnO) nanoparticles have been attracted for their antibacterial effects along with their safety, suitable physicochemical properties, and cost effectivity. The aim of this study was to synthesize ZnO nanoparticles and investigate their antibacterial effects on multidrug resistant (MDR) uropathogenic bacteria. ZnO nanoparticles were constructed by wet chemical method with inhibitor. Structural and optical evaluation of zinc oxide nanoparticles was performed by Ultraviolet absorption spectroscopy, X-ray diffraction (XRD), and Tunneling microscopy. Uropathogenic bacteria were isolated from the patient’s pediatric urine and identified through biochemical testing. Antibiotic resistance pattern of the isolates was determined by disk diffusion method and the antibacterial activity of ZnO nanoparticles was detected by pour plate method at the concentrations of 0.0125, 0.025, 0.05, 0.1, 0.2, 0.4, and 0.8 g/l. The produced ZnO nanoparticles had a hexagonal shape with the crystal size of 15 nm and an optical size of 3 nm. The minimum effective concentration of these nanoparticles that inhibited the bacterial growth was 0.05 g/l. E.coli was generally found to be the most frequent cause of UTI in children in Isfahan, in the center of iran, with the mean prevalence of 64%. Most cases of resistance were related to Ampicillin, Amoxicillin, Tetracycline and the highest sensitivity was related to Chloramphenicol, Gentamicin, Trimethoprim/Sulfamethoxazol. The results of the present study, in accordance to the previously approved safe characteristics of ZnO nanoparticles, concentration of 0.05 g/l is proposed to be evaluated for in vivo usage for treatment of urinary tract infections. | ||
کلیدواژهها | ||
Uropathogenic bacteria؛ Multidrug resistant؛ Zinc oxide Nanoparticles؛ Wet chemical method؛ Pour plate method | ||
آمار تعداد مشاهده مقاله: 253 |