Synthesis Of Some New Thiazolidinones Derived From 1-P-Tolylethanone And Their Antibacterial And Antifungal Activities

International Journal of Industrial Chemistry

دوره 2، شماره 1، خرداد 2011، صفحه 45-51   

نوع مقاله: research article

نویسندگان

Jitesh B. Patel؛ Vikas A. Desai^*

Department of Chemistry, B.K.M. Science College, Valsad, 396001, Gujarat, India

چکیده

Some new 3- (substitutedphenyl) -2-methyl-2-p-tolylthiazolidin-4-ones (3a-t) were prepared by refluxing the 1-p-tolylethanone (1) with different aromatic amines (2a-t) in presence of thioglycolic acid in benzene (one pot synthesis). The title compounds have been characterized on the basis of elemental analysis, IR, 1 H-NMR and13 C-NMR spectral data. All the synthesized compounds have been screened against four different bacterial strains S. aureus, S. paratyphi-A, E. coli and B. subtilis and fungal strain F. molaniforme and A. niger. Some of them showed good antibacterial and antifungal activity compared to reference drugs used in the study.

کلیدواژه‌ها

ANTIBACTERIAL؛ ANTIFUNGAL؛ ONE POT SYNTHESIS؛ 1-P-TOLYLETHANONE