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Sedighi, Mehrnoosh, Namdari, Mehrdad, Mahmoudi, Payam, Khani, Afshin, Manouchehri, Aliasghar, Anvari, Milad. (1402). An Overview of Angiogenesis and Chemical and Physiological Angiogenic Factors: Short Review. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 13(3), 411-422. doi: 10.22034/jchr.2022.1932834.1326
Mehrnoosh Sedighi; Mehrdad Namdari; Payam Mahmoudi; Afshin Khani; Aliasghar Manouchehri; Milad Anvari. "An Overview of Angiogenesis and Chemical and Physiological Angiogenic Factors: Short Review". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 13, 3, 1402, 411-422. doi: 10.22034/jchr.2022.1932834.1326
Sedighi, Mehrnoosh, Namdari, Mehrdad, Mahmoudi, Payam, Khani, Afshin, Manouchehri, Aliasghar, Anvari, Milad. (1402). 'An Overview of Angiogenesis and Chemical and Physiological Angiogenic Factors: Short Review', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 13(3), pp. 411-422. doi: 10.22034/jchr.2022.1932834.1326
Sedighi, Mehrnoosh, Namdari, Mehrdad, Mahmoudi, Payam, Khani, Afshin, Manouchehri, Aliasghar, Anvari, Milad. An Overview of Angiogenesis and Chemical and Physiological Angiogenic Factors: Short Review. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1402; 13(3): 411-422. doi: 10.22034/jchr.2022.1932834.1326

An Overview of Angiogenesis and Chemical and Physiological Angiogenic Factors: Short Review

Journal of Chemical Health Risks
دوره 13، شماره 3، آذر 2023، صفحه 411-422    اصل مقاله (557.87 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22034/jchr.2022.1932834.1326
نویسندگان
Mehrnoosh Sedighi1؛ Mehrdad Namdari1؛ Payam Mahmoudi2؛ Afshin Khani2؛ Aliasghar Manouchehri* 3؛ Milad Anvari4
1Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khoramabad, Iran
2Cardiovascular Research Center, Mazandran Heart Center, Sari, Iran
3Assistant Professor, Department of Internal Medicine, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran
4Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
چکیده
Angiogenesis refers to the formation of new blood vessels from existing ones, which can occur in both physiologic and pathologic conditions. Lack of tissue oxygen is the main stimulator of angiogenesis accompanied by increasing in HIF-1α-(hypoxia-inducible factor-1α) expression as a nuclear transcription factor. Other factors such as VEGF (vascular endothelial growth factor), FGF2 (fibroblast growth factor2), and TGF (transforming growth factor) are involved in angiogenesis, too. To control diabetes and tumoral disease, abnormal angiogenesis inhibition can be useful besides stimulation that can be helpful in cardiovascular disease. In this study, we have reviewed the mechanisms and stimulators of angiogenesis and its influential factors. The most important angiogenic factors are MMP, Ang, FGF, and VEGF. Ang is not directly involved in the process of angiogenesis but sometimes destabilize the arteries. In contrast to angiostatin, endostatin TIMP and TSP1 act as the most important angiostatic factors. Many attempts have been made to identify the mechanisms and factors involved in this process but angiogenic inhibitors that inhibit the growth of cancerous masses or tumors in the body have not yet been adequately investigated
کلیدواژه‌ها
Heart؛ Angiogenesis؛ Angiogenic factors؛ VEGF؛ TGF
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