Preparation, Characterization and Antibacterial Activity of some New Oxazolidin-5-one Derivatives Derived from Imine Compounds

Journal of Chemical Health Risks

دوره 12، شماره 4، اسفند 2022، صفحه 725-732   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.22034/jchr.2022.688557

نویسندگان

Rasim Farraj Muslim¹؛ Ismaeel Yaseen Majeed^{* 2}؛ Suheb Eaid Saleh³؛ Marwan Mahmood Saleh⁴؛ Mustafa Nadhim Owaid⁵؛ Jalal Abdulkareem Abbas⁶

¹Department of Environmental Sciences, College of Applied Sciences-Hit, University of Anbar, Hit, Anbar, Iraq

²Department of chemistry, College of education for pure science-Ibn Al-Haitham University of Baghdad, Baghdad, Iraq

³Directorate of Education in Anbar, Ministry of Education, Ramadi, Anbar 31001, Iraq

⁴Department of Biophysics, College of Applied Sciences-Hit, University of Anbar, Hit, Anbar, Iraq

⁵Department of Heet Education, Directorate of Education in Anbar, Ministry of Education, Hit, Anbar, Iraq

⁶Department of Chemistry, Faculty of Science, Gazi University, Teknikokullar, Ankara, Turkey

چکیده

In this research, 5- membered heterocyclic compounds as oxazolidine-5-one J₁-J₅ derivatives were prepared using primary aromatic amine, aromatic carbonyl compounds and chloroacetic acid. By combining primary aromatic amines and aromatic carbonyl compounds, Schiff's bases were synthesized. Schiff bases are used with the chloroacetic acid compound to prepare oxazolidine-5-one J₁-J₅ derivatives. The compounds J₁-J₅ were described using NMR spectroscopy and FT-IR. .The biological efficacy was evaluated according to maximum inhibitory concentrations (MICs) toward Staphyloccoccus aureus and Esherichia coli. The best MIC was 210 μg ml^-1 for J₄ against the two pathogenic bacteria, while J₁, J₄, and J₁ did not show any inhibitory effect against all bacteria. Finally, the best chemical created, 3'-(pyrimidin-2-yl) spiro[indoline-3,2'-oxazolidine]-2,5'-dione (J4), inhibited the development of both gram-negative and positive bacteria.

کلیدواژه‌ها

Heterocyclic؛ Oxazolidine-5-one؛ Biological activity؛ MICs

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