Investigation of IgG antibody levels among healthcare workers vaccinated with inactivated COVID-19 vaccine using indirect ELISA

International Journal of Molecular and Clinical Microbiology

دوره 12، شماره 1، شهریور 2022، صفحه 1586-1595   

نوع مقاله: Research Article

نویسندگان

Mehmet Nuri ACIK^{* 1}؛ Gülden Eser Karlıdağ²؛ Burcu Karagülle³؛ Tugce Atcali⁴؛ Cihat Uçar⁵؛ Faruk Dişli⁶؛ Seda Yakut⁷؛ Sedat Yıldız⁶؛ Burhan CETINKAYA⁸

¹Bingol University, Veterinary Faculty, Microbiology Department, 12000 Bingol/TURKEY

²2University of Health Sciences, Fethi Sekin City Hospital, Clinic of Infectious Diseases and Clinical Microbiology, Elazig, Turkey

³Department of Microbiology, Faculty of Veterinary Medicine, University of Firat, Elazig, Turkey

⁴Department of Physiology, Faculty of Veterinary Medicine, University of Bingol, 12000, Bingol-Turkey;

⁵Department of Physiology, Faculty of Medicine, University of Adıyaman, Adıyaman, Turkey

⁶Department of Physiology, Faculty of Medicine, University of Inonu, Malatya, Turkey

⁷Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Bingol, 12000, Bingol-Turkey

⁸Firat University

چکیده

This study was conducted to investigate variations in SarsCoV-2-specific IgG levels over a 5-month period in healthcare workers who received two doses of CoronaVac vaccine.  Blood samples were collected from 122 participants on days 14, 56 and 150 following the second dose of the vaccination. SarsCoV-2 specific IgG antibody titres of the participants were measured using the QuantiCOR ELISA kit. Demographic data of the participants were recorded. Seropositivity on 14th, 56th and 150th days in the previously uninfected group was 44.8%, 50.7% and 32.8%, respectively. In the previously infected group, seropositivity was detected in 87.2%, 92.7% and 43.6% of the participants, respectively. While a statistically significant difference was determined between the two groups in terms of seropositivity on the 14th and 56th days, no statistical difference was found on the 150th day. The data of this study indicated that the CoronaVac vaccine provided sufficient immunity in previously infected individuals, though the duration of immunity was short. It is suggested that CoronaVac vaccine would be more appropriate to use as a booster in order to increase the effectiveness of a vaccine rather than the first vaccination, or to vaccinate people who have been infected before.

کلیدواژه‌ها

COVID-19؛ healthcare workers؛ CoronaVac؛ IgG؛ ELISA