مروری بر تشکیل بیوفیلم و کوروم سنسینگ در باکتری سودوموناس آئروژینوزا

فصلنامه کیفیت و ماندگاری تولیدات کشاورزی و مواد غذایی

دوره 1، شماره 3، اسفند 1400، صفحه 16-30   

نوع مقاله: مقاله پژوهشی

شناسه دیجیتال (DOI): 10.30495/qafj.2022.1950481.1022

نویسندگان

راضیه بهزادمهر¹؛ مریم بیگمی²؛ سعیده سعیدی^{* 3}

¹دانشیار، گروه رادیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی زابل، زابل، ایران

²استادیار، گروه صنایع غذایی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران

³کارشناسی ارشد، پژوهشکده زیست‌فناوری کشاورزی، دانشگاه زابل، زابل، ایران

چکیده

چکیده:
سودوموناس آئروژینوزایک پاتوژن فرصت طلب و عامل10الی15درصد از عفونت های بیمارستانی میباشـد.وجـود ژن هـایحدت یکی از مهمترین مکانیسم های تهاجمی سودوموناس آئروژینوزامیباشد و این موضوع از نظر پزشـکی از اهمیـت ویـژه ای برخـورداراست.بیان بسیاری از ژن های بیماریزای باکتری سودوموناس آئروژینوزابه وسیله یک سیستم ژنی بـه نـام سیسـتمQuorum Sensing(QS)کنترل و تنظیم میگردند. کروم سنسینگ سیستم ارتباطی سلول به سلول با استفاده از مولکولهـای کوچـکSMsدر ارگانیسـم های تک سلولی است.هدف از تحقیق بررسی تشکیل بیوفیلم در سیستم کروم سنسـینگ در سـویه هـایسـودوموناس آئروژینـوزامیباشد. مطالعه مروری حاضر با کمک مقالات نمایهشده درپایگاههای علمی فارسی Magiran و SID وپایگاههای علمی انگلیسی Scopus، Google scholar، Ebscohostو Science Directبدست آمد.ژنهای سیستم QSفراوانی بالایی در بین سویه های سودوموناس آئروژینوزاجداشده از منابع انسانی دارند.همچنین این باکتری بعنوان یک باکتری عفونت زابا مقاومت آنتی بیوتیکی بالا میباشد.نتایج مطالعه نشان داد که گیاهان دارویی در رقت های مختلف مهار کننده کوروم سنسینگ و بیوفیلم در باکتری ها می باشند.

کلیدواژه‌ها

کوروم سنسینگ؛ سودوموناس آئروژینوزا؛ بیوفیلم؛ عصاره گیاه

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