Smirnovia Iranica Whole Herb Extract: Antioxidant, Radical Scavenging, Anti-microbial and Anti-Cancer Effects

Journal of Chemical Health Risks

دوره 13، شماره 2، شهریور 2023، صفحه 391-400   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.22034/jchr.2022.1943420.1443

نویسندگان

Leila Monjazeb Marvdashti^{1، 2}؛ Samaneh Arab^{3، 4}؛ Marjan Bahraminasab^{3، 4}؛ Mina Roustaei⁵؛ Samaneh Souri⁵؛ Mojtaba Heydari Majd⁶؛ Anna Abdolshahi^{* 1}

¹Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan, Iran

²Cancer Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran

³Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran

⁴Department of Tissue Engineering and Applied Cell Sciences, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

⁵Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran

⁶Zabol University of Medical Sciences, Zabol, Iran

چکیده

In this study, the biological activities of whole herb extract of a medicinal plant named Smirnovia Iranica were investigated. The extraction was performed using Supercritical CO₂ and phytochemical compounds, total phenolic content (TPC), total flavonoid content (TFC), antioxidant, anti-bacterial, and anti-cancer effect were determined in the extract. Based on the results, high TPC concentration (120.36 mg GAE/100 g FW) and TFC (17.41 mg quercetin/100g FW) were obtained in the extract. Besides, the extract showed significant antioxidant activity (IC50=53.97 µg mL^-1). Moreover, the extract showed a notable inhibitory effect against Escherichia coli (MIC=15.63 mg mL^-1) and Salmonella enterica (MIC=31.25 mg mL^-1). On the other hand, this extract showed the cytotoxic effect on glioblastoma cancer cell lines in the MTT assay. This is the first, yet comprehensive, scientific report about the chemical composition and pharmacological properties of the extract of Smirnovia Iranica whole herb. According to current results, the Smirnovia Iranica extract has excellent antioxidant properties for application as bioactive components for various objects such as as food supplements. The experiment confirmed the efficacy of the extracts as natural antimicrobials and suggested the possibility of employing them in drugs for the treatment of infectious diseases caused by the test organisms.

کلیدواژه‌ها

Anti-Microbial Agents؛ Anti-Oxidant effect؛ Anticancer agent؛ Smirnovia Iranica؛ IC50

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