Development and Evaluation of Nanomagnetic Carrier for the Controlled Loading and Release of Celecoxib

Journal of Advanced Materials and Processing

دوره 10، شماره 1 - شماره پیاپی 37، فروردین 2022، صفحه 13-26   

نوع مقاله: Research Paper

نویسندگان

Shabnam Ahmadvand¹؛ Maryam Kargar Razi^{* 1}؛ Babak Sadeghi²؛ Seyedeh Sara Mirfazli³

¹Department of Chemistry, Islamic Azad University, North Tehran Branch, Tehran, Iran

²Department of Chemistry, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran

³Department of Medicinal Chemistry, School of Pharmacy International Campus, Iran University of Medical Sciences, Tehran, Iran

چکیده

The aim of the present study was to develop synthesize, characterize, and find many applications of functionalized metal oxide nanoparticles. Herein, a new strategy is developed to functionalize magnetite nanoparticles to improve their performances of cerium oxide-functionalized Fe₃O₄@SiO₂@CeO₂ magnetic nanoparticles (FSC). In this study, after preparing optimized FSC, characterization and identification of their chemical structure were carried out by FT-IR, FESEM, VSM, TGA, DLS, and XRD. Afterward, the functionalized nanoparticles were examined in the delivery of celecoxib as an active drug model involving cerium oxide and hydroxyl functional groups. The results with respect to particle size, present investigation indicate that the formulations (m_FSC=5 mg, pH=3.3) can be considered as best among various formulations. Dynamic light scattering (DLS) techniques used to measure particle size and zeta potential distribution revealed successful preparation of an Fe₃O₄@SiO₂@CeO₂  nanocomposite prepared on Fe₃O₄@SiO₂ (FS), with a hydrodynamic size distribution of 45 nm.

کلیدواژه‌ها

Dynamic Light Scattering (DLS)؛ Magnetite؛ Nanocomposite؛ Celecoxib؛ TGA

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