Preparation of Efficient Kit for the Semi-Quantitative Determination of Sarcosine as a cancer marker by Grafting Molecularly Imprinted-Stationary on Glass Plate

Journal of Chemical Health Risks

دوره 13، شماره 2، شهریور 2023، صفحه 259-266   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.22034/jchr.2022.693893

نویسندگان

Nahid Farhadgholami¹؛ Hamid Hashemi-Moghaddam^{* 2}؛ Masoud Shaabanzadeh²؛ Saeed Zavareh³

¹Department of Chemical Engeenering, Damghan Branch, Islamic Azad University, Damghan, Iran

²Department of Chemistry, Damghan Branch, Islamic Azad University, Damghan, Iran

³Department of Biology, Damghan University, Damghan, Iran

چکیده

This paper presents a novel, rapid, and simple method for the determination of sarcosine. The surface of a glass plate was modified with 3-(methacryloxy)propyltrimethoxysilane. Then, a sarcosine-imprinted polymer was grafted on the glass plate by copolymerization of the vinyl end groups with a functional monomer and a cross-linking agent. The synthesized polymers were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. In the subsequent step, the determination of sarcosine was conducted using the synthesized kit in optimized conditions. The synthesized grafted plate was able to absorb sarcosine selectively in the presence of other amino acids, showing that the proposed method enabled the rapid determination of sarcosine. 

کلیدواژه‌ها

Imprinted polymer؛ Sarcosine؛ Kit؛ Grafting

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