The Effect of Aspirin on the World's Pandemic COVID-19

Biotechnological Journal of Environmental Microbiology

مقاله 3، دوره 1، شماره 1، خرداد 2022، صفحه 23-36   

نوع مقاله: Review Article

شناسه دیجیتال (DOI): 10.30495/bioem.2022.695067

نویسندگان

Masoumeh Heidaritajan^{* 1}؛ Maryam Jafarian Anvar²؛ Seyed Amirali Ghasemi³

¹Department of Medical Science, Faculty of Medicine, University of Georgia, Tbilisi, Georgia

²Department of Medical Science, Faculty of Medicine, University of Georgia, Tbilisi, Georgia

³Student research Commitee , School of Dentistry , Guilan university of Medical Sciences , Rasht , Iran

چکیده

Aspirin has become one of the most frequently used and cheapest drugs in medicine till now. Since its first synthesis in 1897, several medicinal roles and mechanisms of action of Aspirin have become apparent. Since its emergence, the COVID-19 pandemic has been ravaging the medical and economic sectors even with the significant vaccination advances. In severe presentations, the disease of SARS-CoV-2 can manifest with life-threatening thromboembolic and multi-organ repercussions provoking notable morbidity and mortality. Aspirin, due to its well-known properties and multiple molecular targets, and ought to its extensive clinical use, has been perceived as a potential therapeutic agent for COVID-19. Aspirin acts at multiple cellular targets to achieve its anti-inflammatory and anti-platelet effects. Although initial promising clinical data describing aspirin role in COVID-19 has appeared, evidence supporting its use remains fragile and premature. In this article, we highlight the history of Aspirin, a novel mechanism of action, and its uses. Also included is a brief statement of emerging new applications and principal mechanisms by which Aspirin inhibits acute inflammation and alters platelet-biology; therefore, hypothesized that Aspirin might prove highly beneficial as a novel therapeutic drug for combating severe acute inflammation and thrombosis associated with the cytokine storm in COVID -19 patients.

کلیدواژه‌ها

Aspirin؛ mechanism of action؛ uses؛ COVID-19