Label-Free Perfect Separation of Michigan Cancer Foundation-7 Cells from White Blood Cells using Both Wall-Induced Lift and Dielectrophoresis Forces

ADMT Journal

دوره 15، شماره 3، آذر 2022، صفحه 99-107   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.30486/admt.2022.1957227.1347

نویسندگان

Alireza Alaghemand؛ Ali Fattah^*

Electrical Engineering Department, Shahrood University of Technology, Shahrood, Iran

چکیده

A microchannel device was designed and utilized to separate Michigan Cancer Foundation-7 cells from white blood cells using both wall-induced lift and di-electrophoresis forces. Using COMSOL Multiphysics simulator, the label-free separation process is performed based on the radius size of the particles. The best performance of the structure is obtained with the efficiency of 100% and 99% for cancer and white blood cells separation processes, respectively. For the proposed microfluidic structure, in addition to the highest available efficiency and high separation speed of 12 um/s, the low DC voltage of 6 V is applied, which causes negligible damage to the blood cells.

کلیدواژه‌ها

Cancer Cells؛ COMSOL؛ Dielectrophoresis؛ Microfluidics؛ Separation

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