The Modulatory effects of Allium cepa and quercetin on the atherogenic, serum biochemical, and haematologic indices in potassium bromated induced toxicity in male Wistar rats

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

دوره 13، شماره 2، آبان 2022، صفحه 49-57   

نوع مقاله: Original article

شناسه دیجیتال (DOI): 10.30495/medherb.2022.696619

نویسندگان

Solomon Agu^{* 1}؛ Ahmed Alabi Akintola²؛ Deborah Oluwaseun Meshioye²؛ Michael Adedapo Gbadegesin²؛ Oyeronke Adunni Odunola²

¹Department of Veterinary Physiology and Biochemistry. Federal University of Agriculture, Makurdi, Benue State, Nigeria;

²Cancer Research and Molecular Biology Laboratory, Department of Biochemistry, University of Ibadan,Ibadan, Oyo State, Nigeria;

چکیده

Background & Aim: This study was designed to evaluate the therapeutic effect of Allium cepa on the atherogenic, serum biochemical, and hematologic indices in Wistar rats administered KBrO₃.
Experimental: Forty male rats assigned into 8 groups (n=5) in which groups A, B, C, D, and E received distilled water (2 mL), KBrO₃ (50 mg/kg), quercetin 70 mg/kg, aqueous extract of Allium cepa (AEAC) at 150 mg/kg and 300 mg/kg, respectively. Groups F, G, and H received KBrO₃ with AEAC at 150 mg/kg, 300 mg/kg, and quercetin, respectively, on alternate days for 3 months.
Results: The phytochemical analysis of the AEAC revealed the presence and absence of some phytochemical constituents. The Acute toxicity result indicated that AEAC has an LD50 above 5000mg/kg. KBrO₃ caused a significant (P<0.05) decrease in the haematological parameters relative to the control but administration of KBrO₃ with AEAC or quercetin improved the parameters. KBrO₃ caused a significant (P<0.05) increase in the levels of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), but significantly (P<0.05) lower level of HDL-C. Treatment with KBrO₃ and AEAC or quercetin significantly (P<0.05) abrogated these KBrO₃-induced alterations. Similar ameliorative effects of AEAC were found in KBrO₃-induced alterations in atherogenic indices, such as Castelli's Risk Index I (CRI-1), Castelli's Risk Index II (CRI-II), Atherogenic Coefficient (AC), and Atherogenic Index of Plasma (AIP) indices relative to the control.
Recommended applications/industries: According to the present results, AEAC showed amelioration against KBrO₃-induced derangement in the haematological, lipid, and atherogenic indices and it might be helpful in the management of cardiovascular problems.

کلیدواژه‌ها

Atherogenicity؛ Haematology؛ KBrO3؛ Lipid profiles؛ Onions

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