Green Synthesis and Investigation of Antioxidant Activity of New Quinoline Derivatives

Journal of Applied Chemical Research

دوره 16، شماره 4، دی 2022، صفحه 8-27   

نوع مقاله: Original Article

نویسندگان

Seyyed Ali Moghaddas¹؛ Zinatossadat Hossaini^{* 2}؛ Daryoush Zareyee²

¹Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran

²Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.

چکیده

New derivatives of furo[2,3-f]quinoline derivatives in high yields using multicomponent reaction of 
the  2-amino-4-hydroxyacetophenone,  isopropenylacetylene,  aldehydes  and  malononitrile  or  ethyl 
cyanoacetate in the presence of catalytic amounts of Fe3O4/KF/Clinoptilolite@MWCNTs magnetic 
nanocomposites  using  ionic  liquid  as  green  solvent  at  room  temperature  were  synthesized.  This 
catalyst could be employed several times in these reactions and have the main role in the yield of 
the product. The synthesized compounds have NH group in their structure and for this reason, have 
good  antioxidant  activity. Our  procedure  for  preparation  of furo[2,3-f]quinoline  derivatives has 
some advantages such as low reaction time, the product with high yields, and simple separation of 
catalyst and products. 

کلیدواژه‌ها

Fe3O4/KF/Clinoptilolite@MWCNTs؛ Furo[2؛ 3-f]quinoline؛ Multicomponent reactions؛ 2-amino-4-hydroxyacetophenone؛ Isopropenylacetylene؛ Ethyl cyanoacetate

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