One pot Solvent free Synthesis of Biginelli Type Derivatives using Ag2O/GO/TiO2 Composite Nanostructure and evaluation of biological activity

Journal of Chemical Reactivity and Synthesis

دوره 12، شماره 4، اسفند 2022، صفحه 295-308   

نوع مقاله: Research Article

نویسندگان

Fatemeh Samandizadeh¹؛ Mohammad Kazem Mohammadi^{* 2}؛ Ayeh Rayatzadeh¹؛ Neda Hasanzadeh¹

¹Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.

²Advanced Surface Engineering and Nano Materials Research Center, Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

چکیده

The Biginelli Reaction is a one-pot acid catalysed cyclocondensation of -keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalised 3,4-dihydro-2(H)-pyrimidinones (DHPMs). This three-component reaction for the synthesis of dihydropyrimidinone and corresponding dihydropyrimidinethiones has now been known for more than a century since first reported in 1893. The classical reaction has been modified in the recent past by using various catalysts and several structural variants in different solvents to synthesize large number of Biginelli type compounds. Also, these DHPMs (synthetic and natural) possess a wide range of pharmacological activities.

کلیدواژه‌ها

Dihydropyrimidinone؛ dihydropyrimidinethione؛ multicomponent reactions؛ Ag2O/GO/TiO2