Investigation of the Nonlinear Refractive Index of MCF7 and MCF10A Breast Cell Lines for Optical Diagnosis

International Journal of Biophotonics and Biomedical Engineering

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 24 بهمن 1401

نوع مقاله: Research article

شناسه دیجیتال (DOI): 10.30495/ijbbe.2023.1969265.1016

نویسندگان

Bahareh Khaksar Jalali^{* 1}؛ Somayeh Salmani Shik²؛ Latifeh Karimzadeh Bardee³؛ Sharife Shahi⁴

¹Department of physics, Kharazmi University, Tehran, Iran

²1. Department of physics, Kharazmi University, Tehran, Iran. 2. Applied Sciences Research Center, Kharazmi University, Karaj, Iran.

³Department of animal biology, Faculty of biological sciences, kharazmi university, Tehran, Iran.

⁴1. Department of Biomedical Engineering, Islamic Azad University of Isfahan (Khorasgan) branch, Isfahan, Iran. 2. Laser and Biophotonics in Biotechnologies Research Center, Islamic Azad University of Isfahan (Khorasgan) branch, Isfahan, Iran.

چکیده

To demonstrate that the Z-scan approach is a reliable tool for diagnosing normal and cancer cells, the absorption coefficient (α) and nonlinear refractive index (n2) of normal (MCF10A) and cancer cell lines (MCF7) were examined as linear and nonlinear optical properties. Cancer cells had a higher absorption coefficient than normal cells, according to the findings. Cancer cells exhibit a greater nonlinear refractive index (n2) and distinct signs, despite being in the same order (10-7 cm2/W). This method is a quick method for differentiating between normal and cancerous breast cells, making it suitable for use in clinical stages in the future. This is because of the obvious fundamental difference between the optical behaviour of normal and cancer cells, as well as the affordability, the potential for reproducibility without compromising sample quality, and the high accuracy.

کلیدواژه‌ها

Cancer Diagnosis؛ Linear Absorption؛ MCF7؛ MCF10A؛ Optical Coefficients؛ Z-scan Technique