1D Photonic Crystal Based-Biosensor for Multiple Biomarkers Detection

International Journal of Biophotonics and Biomedical Engineering

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 06 اسفند 1401   

نوع مقاله: Research article

شناسه دیجیتال (DOI): 10.30495/ijbbe.2023.1974383.1019

نویسندگان

Farzaneh Bayat^{* 1}؛ Kazem Jamshidi-Ghaleh²

¹Azarbaijan Shahid Madani University, Tabriz, Iran

²Azarbaijsn Shahid Madani University, Tabriz, Iran

چکیده

In this work, a highly sensitive 1D photonic crystal (1DPC) based biosensor is introduced and theoretically studied using the transfer matrix method, which has the capability of detecting multiple biomarkers, simultaneously. An m by n gradient refractive index (GRIN) lens array is introduced to the center of a 1DPC structure as a defect layer that is surrounded by two microfluidic channels. By irradiating a white light source to the structure, a multiplex array of the concentric rainbow appears on the output plane. The frequency range of these rainbows is highly dependent on the effective refractive index of the fluid inside the two microfluidic channels. By functionalizing the surfaces around the channels with an m by n antibody array and interacting with the various biomarkers with them, each element of the rainbow array displays the changes in the concentration of a different biomarker. Any change in the concentration of the biomarkers can cause a variation in the effective refractive index of the fluid and it leads to a shift in the produced rainbow frequency range on the output plane. The size and number of the generated rainbow array can be engineered by the central defect layer's refractive index distribution function.

کلیدواژه‌ها

Biosensors؛ Defect layers؛ Gradient refractive index lenses؛ One-dimensional photonic crystals؛ Transfer matrix method

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