Evaluation the effect of common thistle (Cirsium vulgare) and thyme (Thymus vulgaris) derived extracts on cutaneous lesions healing in Holstein heifers

Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug)

دوره 13، شماره 4، خرداد 2023، صفحه 49-54   

نوع مقاله: Original article

شناسه دیجیتال (DOI): 10.30495/medherb.2023.701055

نویسندگان

Mehdi Farid^{* 1}؛ Yaser Rahimian²؛ Mohammad Alavi³

¹Department of Veterinary, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran;

²Department of Animal Science, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran;

³Department of Herbal plant Science, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran;

چکیده

Background & Aim: Skin wounds are frequently encountered in heifers because of management practices that use bloody interventions, or owing to lesions caused by unsound installations or fights for establishment of herd hierarchy and lead to the development of myiasis with potential economic losses. Plants derived extracts increase healing and tissue regeneration through multiple connected mechanisms and have synergistic effect on the overall wound healing efficiency. Thyme and common thistle active compounds derived extracts have significant effects for proper wound remedy. The aim of this study was to determine the effect of common thistle and thyme derived extracts on Holstein heifer’s cutaneous skin lesions by second intention.
Experimental: The twenty Holstein heifers by average age, 15 months and average weight of 250±50 kg were selected to evaluate cutaneous lesions healing after treatment with common thistle and thyme derived extracts. Experimental wound excision model in heifers was created by means of a skin punch of 2cm diameter. The heifers were topically treated for 17 days with a saline control or decoctions of mixed with common thistle and thyme derived extracts with carboxymethyl cellulose. The centripetal retraction, clinical, and histological aspects of the wounds were observed until complete healing.
Results: The phototherapeutics agent presents in thyme improved cicatrization of cutaneous lesions in cattle skin during the first days of treatment. The treatments were beneficial to the reparation process. The phytotherapeutics agent present in thyme and common thistle derived extracts exhibited positive effects in the inflammatory phase and on the reparation process. The herbal extract exhibited a positive effect on the macroscopic aspect of cutaneous lesions in cattle only during the first treatment days.
Recommended applications/industries: Both thyme and common thistle extracts improved fibroplasia. Phytotherapeutic activity of thyme was the most superior, and they may be used in topical treatment of cutaneous lesions in Holstein heifers.

کلیدواژه‌ها

Common thistle؛ Cutaneous lesions healing؛ Holstein heifers؛ Thyme

مراجع

Armstrong, D., G. and Jude, E.B. 2002. The role of matrix metalloproteinases in wound healing. Journal of the American Podiatric Medical Association, 92(1): 12–18.

Alam, G., Singh, M.P. and Singh, A. 2011. Wound healing potential of some medicinal plants. International Journal of Pharmaceutical Sciences Review and Research, 9: 136-145.

Arun, S., Satish, S. and Anima, P. 2016. Evaluation of wound healing, antioxidant and antimicrobial efficacy of Jasminum auriculatum Vahl. Leaves. Avicenna Journal of Phytomedicine, 6(3): 295-304.

Barakat, H., Aljabeili., H.S. and Abdel-Rahman, H.A. 2018. Synergistic effect of Thymus vulgaris essential oil oral administration on topically treated wound with Chitosan, thyme essential oil and their combination in rats. Journal of Nutrition and Food Sciences, 8: 695-700.

Bazzaz, B. and Haririzadeh, G. 2003. Screening of Iranian plants for antimicrobial activity. Pharmaceutical Biology, 41: 573–583.

Bowler, P.G. 2002. Wound pathophysiology, infection and therapeutic options. Annals of Medicine, 34: 419–427.

Borawska, M. H., Czechowska, S. K., Markiewicz, R., Socha, K., Nazaruk, J., Pałka, J. and Isidorov, V. A. 2010. Enhancement of antibacterial effects of extracts from Cirsium species using sodium picolinate and estimation of their toxicity. Natural Product Research, 24(6): 554-561.

Braga, P. C., Dalsasso, M., Culici, T., Bianchi, L. and Bordoni, L. 2006. Antiinflammatory activity of thymol: inhibitory effect on the release of human neutrophil elastase. Pharmacology, 77: 130-136.

Busti, A.J., Hooper, C.J., Amaya, S. and Kazi, S. 2005 Effects of perioperative anti-inflammatory and immunomodulating therapy on surgical wound healing. Pharmacotherapy, 25: 1566-1591.

Costa, M.F., Durço, A.O, Rabelo, T.K, Barreto, R.S.S, Guimaraes, A.G. 2019. Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review. Journal of Pharmacy and Pharmacology, 71(2):141-155.

Dorai, A. A. 2012. Wound care with traditional, complementary and alternative medicine. Indian Journal of Plastic Surgery, 45: 418–424.

Guo, S. and DiPietro, L. A. 2010. Factors affecting wound healing. Journal of Dental Research, 89: 219–229.

Gupta, A., Singh, R. L. and Raghubir, R. 2002. Antioxidant status during cutaneous wound healing in immunocompromised rats. Molecular and Cellular Biochemistry, 241(1-2):1–7.

Henry, G. and Garner, W. L. 2003. Inflammatory mediators in wound healing. Surgical Clinics of North America, 83: 483–507.

Kondo, T. and Ishida, Y. 2010. Molecular pathology of wound healing. Forensic Science International. 203: 93–98.

Jurjus, A., Atiyeh, B. S. and Abdallah I.M. 2007. Parmacological modulation of wound healing in experimental burns. Burns, 33: 892–907.

McAnulty, R.J. 2007. Fibroblasts and myofibroblasts, their source, function and role in disease. International Journal of Biochemistry and Cell Biology, 39:666–671.

Matthew, A. 2014. Cirsium vulgare and Spondyloarthropathy. Medical Herbalism. 17(2):12-15.

Mathew, A., Taranalli, A. and Torgal, S. 2004. Evaluation of anti-inflammatory and wound healing activity of Gentiana lutea rhizome extracts in animals. Pharmaceutical Biology, 42:8–12.

Mollarafie, P., Khadivparsi, P., Zarghami, R., Aminifazl, M. and Ghafarzadegan, R. 2015. Antibacterial and wound healing properties of Thymol (Thymus vulgaris oil) and its application in a novel wound dressing. Journal of Medicinal Plants. 14(53): 69-81.

Pawar, R. S. and Toppo, F.A. 2012. Plants that heal wounds. A review. Herba Polonica, 58:47–65.

Pazyar, N. Y., Yaghoobi, R., Rafiee, E., Mehrabian, A. and Feily, A. 2014. Skin wound healing and phytomedicine: a review. Skin Pharmacology and Physiology, 27:303–310.

Kurahashi, T. and Fujii, J. 2015. Roles of antioxidative enzymes in wound healing. Journal of Developmental Biology, 3: 57–70.

Samanta, R., Pattnaik, A. K. and Pradhan, K.K. 2016. Wound healing activity of Silibinin in mice. Pharmacognosy Research, 8 (4):298-302.

Sarabahi, S.2012. Recent advances in topical wound care. Indian Journal of Plastic Surgery, 45:379–387.

SAS Institute, SAS/STAT user’s guide for personal computer. 2001. Release 6.12 SAS Institute, Inc., Cary, N.C., USA.

Silva, N.C.C. and Fernandes, A. 2010. Biological properties of medicinal plants: A review of their antimicrobial activity. Journal of Venomous Animals and Toxins including Tropical Diseases, 16: 402-413.

Soltani, A. 2004. Dictionary of medicinal plants. Arjmand Press, Tehran, Iran.

Steel, R., Torrie, J. and Dickey, D. 1997. Principles and procedures of statistics. A Biometrical Approach. 3^th Ed. McGraw-Hill College. USA.

Toklu, H., Tunali-Akbay, T., Erkanli G.2007. Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury. Burns, 33: 908–916.

Zargari. 2001. Medical plants. 2 ^nd Ed. Tehran University Press. Pp.25-36.