Effect of Aerobic Exercise and Cinnamon Extract on Leptin Gene Expression in Liver and Fat Tissues of Male Rats Fed by High Fat Diet

Journal of Chemical Health Risks

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 12 اردیبهشت 1402   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.22034/jchr.2023.1971267.1636

نویسندگان

Maria Dehvari¹؛ AbdolAli BanaeiFar^{* 1}؛ Sajad Arshadi¹؛ Ardeshir Zafari²

¹Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, South Tehran Branch, Islamic Azad University, Tehran, Iran

²Department of Physical Education and Sports Sciences, Zanjan Branch, Islamic Azad University, Zanjan, Iran

چکیده

Considering the desired effect of aerobic exercise, the effect of high-fat diets on obesity, and the beneficial effects of cinnamon; the present research seeks to answer the question of whether the implementation of aerobic exercise and cinnamon extract have different effects on the relative expression of leptin gene in the liver and fat tissues and also the mass of liver and fat tissues of male rats fed with a high-fat diet. The present experimental research was conducted using an animal model in the form of multi-group research (five groups: 1. control, 2. high-fat diet, 3. cinnamon extract and high-fat diet, 4. aerobic exercise and high-fat diet, 5. aerobic exercise and cinnamon extract and high-fat diet) Independent variables included aerobic exercise and cinnamon extract gavage of high-fat diet is also considered as a background variable. And Dependent variables are the level of leptin gene expression in the tissue of fat and liver, as well as body weight and the weight of liver and fat tissues. All groups received high_fat food in addition to normal food. The Training group participated in an aerobic exercise program. Cinnamon extract was given to cinnamon groups. All samples were anesthetized, killed, and operateon. The results show the effect of a high-fat diet on unfavorable changes in leptin gene expression, body weight, and the weight of fat tissue and liver.  Performing aerobic exercise alone, consuming cinnamon extract alone, and the interaction of aerobic exercise and cinnamon extract cause desired changes in leptin gene expression in liver and fat tissue and the weight of liver and fat tissue compared to the high-fat diet group. Therefore; the Recommendation to take cinnamon extract along with exercise can cause desired and useful effects.

کلیدواژه‌ها

Exercise؛ Leptin؛ Obesity؛ Cinnamon؛ Liver؛ High-fat food

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