Valine Consumption And Endurance Exercise Modified The Inflammation In Rat Model Of Anxiety/Depression.

Exercise Physiology and Performance

دوره 1، شماره 1، تیر 2023، صفحه 81-90   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.30486/epp.2023.1966320.1002

نویسنده

Mohammad-Hossein Beigi^*

Silicon Hall: Micro/Nano Manufacturing Facility, Faculty of Engineering and Applied Science, Ontario Tech University, Ontario, Canada.

چکیده

Background: Depression and anxiety are disabling conditions with side effects on cognition, quality of life, memory, and mood. Anxiety is a dysregulated mood condition that could disturb cognition. The present study aimed to evaluate the effect of dietary interventions and endurance training in managing anxiety and depressive symptoms.
Methods: In this study, 30 rats were divided into five groups: Normal group, anxiety/ depression group, rat model of anxiety/depression who consumed valine 3.0 μmol/500 μl intraperitoneal injection once/day for eight weeks, rat model of anxiety/depression who conducted endurance training (32 m/min for 45 minutes/session, six days a week for eight weeks), and rat model of anxiety/depression who conducted endurance training (75% VO2_max) and consumed valine (3.0 μmol/500 μl). The level of anxiety/depression was evaluated by behavior open field tests and relative expression assay of the genes related to the inflammation.
Results: Findings indicated that the expression level of the NF-κB and TNFα significantly increased in the anxiety/depression group. Moreover, the endurance training and consumed valine  improved the NF-κB and TNFα expression in the brain of the rat  model of anxiety/depression. In addition, endurance training and consuming valine  decreased the anxiety/depression level.
Conclusion: Endurance training and consuming valine  reduced the brain's inflammation level and improved the anxiety/depression level. 

کلیدواژه‌ها

Anxiety؛ Depression Valine؛ Endurance training؛ Brain