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Askari, Seyed Fateme, Farhad Mollashahi, Leila, Rigi Ladiz, Mohamad Ayoub, Kordi-Tamandani, Dor Mohammad. (1402). Assessment of MOB1A and B gene polymorphisms in oral lichen planus patients. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1(1), -. doi: 10.30486/cofs.2023.1980851.1001
Seyed Fateme Askari; Leila Farhad Mollashahi; Mohamad Ayoub Rigi Ladiz; Dor Mohammad Kordi-Tamandani. "Assessment of MOB1A and B gene polymorphisms in oral lichen planus patients". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1, 1, 1402, -. doi: 10.30486/cofs.2023.1980851.1001
Askari, Seyed Fateme, Farhad Mollashahi, Leila, Rigi Ladiz, Mohamad Ayoub, Kordi-Tamandani, Dor Mohammad. (1402). 'Assessment of MOB1A and B gene polymorphisms in oral lichen planus patients', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1(1), pp. -. doi: 10.30486/cofs.2023.1980851.1001
Askari, Seyed Fateme, Farhad Mollashahi, Leila, Rigi Ladiz, Mohamad Ayoub, Kordi-Tamandani, Dor Mohammad. Assessment of MOB1A and B gene polymorphisms in oral lichen planus patients. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1402; 1(1): -. doi: 10.30486/cofs.2023.1980851.1001

Assessment of MOB1A and B gene polymorphisms in oral lichen planus patients

Contemporary Orofacial Sciences
مقاله 5، دوره 1، شماره 1، مرداد 2023    اصل مقاله (267.77 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30486/cofs.2023.1980851.1001
نویسندگان
Seyed Fateme Askari1؛ Leila Farhad Mollashahi* 2؛ Mohamad Ayoub Rigi Ladiz3؛ Dor Mohammad Kordi-Tamandani4
1Departemant of oral and Maxillofacial pathology , school of dentistry, Islamic Azad University, Isfahan (Khorasgan) branch, Isfahan, Iran
2Department of Periodontics, Zahedan University of Medical Sciences, Zahedan, Iran
3Department of Oral Medicine, Oral & Dental Disease Research Center, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran
4Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran
چکیده
Background: This study aimed to assess MOB1A and B gene polymorphisms in patients with oral lichen planus (OLP. Several of premalignant lesions such as, leukoplakia, erythroplakia, oral lichen planus (OLP), and submucosal fibrosis can undergo malignant transformation and lead to oral cancer and non-invasive screening of patients to find those susceptible to SCC before progression to cancer would be highly beneficial.
Materials and Methods: This case-control study was conducted on 35 OLP patients and 35 healthy controls presenting to the Oral Medicine Department of Zahedan Dental School 2015 -2017. Unstimulated saliva samples were collected from both groups, and MOB1A and B gene polymorphisms were assessed by polymerase chain reaction (PCR). The two groups were compared by the Chi-square test (alpha=0.05).
Results: Two groups had no significant difference in the frequency of T and G alleles for MOB1A gene polymorphisms. (P>0.05) and either two groups had no significant difference in the frequency of A and C alleles for MOB1B gene polymorphism's (P>0.05).
Conclusion: The present results showed no significant difference between the case and control groups regarding MOB1A and B gene polymorphisms; thus, MOB1A and B gene polymorphisms do not appear to play a role in the pathogenesis of OLP.
کلیدواژه‌ها
Genes؛ Polymorphisms؛ MOB1A؛ MOB1B؛ Lichen Planus؛ Oral
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