The Effect of Rosa Damascena Extract on Diazinon Toxicity in Mice

Journal of Chemical Health Risks

دوره 13، شماره 4، اسفند 2023، صفحه 721-728   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.22034/jchr.2021.1941985.1422

نویسندگان

Oveys Pourmahdi¹؛ Tohid Moradi Gardeshi²؛ Ali Amirkhani¹؛ Majid Gholami-Ahangaran^{* 3}

¹Undergraduate of Veterinary Medicine Faculty, Babol Branch, Islamic Azad University, Babol, Iran

²Undergraduate of Veterinary Medicine Faculty, Garmsar Branch, Islamic Azad University, Garmsar, Iran

³Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

چکیده

Diazinon (DNZ) is one of the most widely used organophosphorus poisons, which plays an important role in chemical pest control by controlling a wide range of chewing and sucking pests in gardens and fields. Diazinon causes death in living organisms by reducing cholinesterase and disrupting nerve cells. In this research, the effect of Rosa damascena extract against DNZ toxicity and oxidative damage induced by DZN in mice was studied. The mice toxified with DNZ (32.5 mg kg^-1, intraperitoneally) and treated by pralidoxime (PM) (20 mg kg^-1, intraperitoneally) or R. Damascena extract (50, 100, 200 mg kg^-1, orally) daily for two weeks. In the end, the acetylcholinesterase (AchE), ferric-reducing antioxidant power (FRAP), Malondialdehyde (MDA), ALT, AST, ALP, and total bilirubin were assayed. DZN administration significantly lowered the AchE, and FRAP and increased the MDA (P < 0.05). However, R. Damascena extracts treatment caused a significant reduction in MDA level and restored the levels of AchE and FRAP as well as significantly prevented the DZN-induced increase in liver aminotransferases, ALP, and total bilirubin. We found that R. Damascena administration nearly eliminated DZN-induced toxicity by preventing oxidative stress in mice.

کلیدواژه‌ها

Diazinon؛ Oxidative stress؛ Rosa damascene؛ Toxicity؛ Mice

مراجع

1. Gholami-Ahangaran M., Peimani N., Ahmadi-Dastgerdi A., 2019. The effect of thyme (Thymus daenensis) supplement on growth and hygienic parameters of broilers meat. Iraqi J Vet Sci. 33(1), 87-92.
2. Rangsaz N., Ahangaran M.G., 2011. Evaluation of turmeric extract on performance indices impressed by induced aflatoxicosis in broiler chickens. Toxicol Ind Health. 27(10), 956-960. DOI:10.1177/0748233711401262.
3. Özkan G., Sagdiç O., Baydar N.G., Baydar H.A., 2004. Antioxidant and antibacterial activities f Rosa damascena flower extracts. Food Sci Technol Int. 10(4), 277-281. DOI:10.1177/1082013204045882.
4. Hajhashemi V., Ghannadi A., Hajiloo M., 2010. Analgesic and anti-inflammatory effects of Rosa damascena hydroalcoholic extract and its essential oil in animal models. Iran J Pharm Sci. 9(2), 163-170.
5. Tabrizi H., Mortazavi S.A., Kamalinejad M., 2003. An in vitro evaluation of various Rosa damascena flower extracts as a natural antisolar agent. Int J Cosmet Sci. 25(6), 259-265. DOI: 10.1111/j.1467-2494.2003.00189.x
6. Boskabady M.H., Shafei M.N., Saberi Z., Amini S., 2011. Pharmacological effects of Rosa damascena. Iran J Basic Med Sci. 14(4), 295-300. DOI: 10.22038/IJBMS.2011.5018.
7. Mahboubi M., 2016. Rosa damascena as holy ancient herb with novel applications. J Tradit Complement Med. 6(1), 10-16. [Doi:10.1016/j.jtcme.2015.09.005.
8. Bani S., Hasanpour S., Mousavi Z., Garehbaghi P.M., Gojazadeh M., 2014. The effect of rosa damascena extract on primary dysmenorrhea: a double-blind cross-over clinical trial. Iran Red Crescent Med J. 16(1), 100-110. DOI: 10.5812/ircmj.14643.
9. Alp H., Sak M.E., Evsen M.S., Firat U., Evliyaoğlu O., Penbegül N., Sancaktutar A.A., Söylemez H., Tuzcu M., 2012. Effects of Malathion in fetal kidney tissues in pregnant rats: Teratogenic effects induced by different doses. Kafkas Univ Vet Fak Derg. 18, 221–226.
10. Boesri H., Heriyanto B., Handayani S.W., Suwaryono T., 2015. Uji toksisitas beberapa ekstrak tanaman terhadap larva Aedes aegypti vektor demam berdarah dengue. Vektora: Journal Vektor dan Reservoir Penyakit. 7(1), 29-38.
11. Payangka J., Risma R., Wibowo P., 2019. Pengaruh Ekstrak Daun Pepaya (Carica papaya) Terhadar Kematian Larve Nyamuk Aedes agypti Instar III. Med Health Sci J. 3(1), 7-16. DOI: 10.33086/mhsj.v3i1.921.
12. Shah M.D., Iqbal M., 2010. Diazinon-induced oxidative stress and renal dysfunction in rats. Food Chem. Toxicol. 48(12), 3345-3353. [Doi: 10.1016/j.fct.2010.09.003].
13. Akturk O., Demirin H., Sutcu R., Yilmaz N., Koylu H., Altuntas I., 2006. The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat heart and ameliorating role of vitamin E and vitamin C. Cell Biol Toxicol.22(6), 455-476. [DOI: 10.1007/s10565-006-0138-5].
14. Ogutcu A., Uzunhisarcikl M., Kalender S., Durak D., Bayrakdar F., Kalender Y., 2006. The effects of organophosphate insecticide diazinon on malondialdehyde levels and myocardial cells in rat heart tissue and protective role of vitamin E. Pestic Biochem Physiol. 86(2), 93-98.
15. Roegge C.S., Timofeeva O.A., Seidler F.J., Slotkin T.A., Levin E.D., 2008. Developmental diazinon neurotoxicity in rats: later effects on emotional response. Brain Res Bull. 75(1), 166-172. Doi: 10.1016/j.brainresbull.2007.08.008.
16. El-Demerdash F.M., Nasr H.M., 2014. Antioxidant effect of selenium on lipid peroxidation, hyperlipidemia and biochemical parameters in rats exposed to diazinon. J Trace Elem Med Biol. 28(1), 89-93. DOI: 10.1016/j.jtemb.2013.10.001.
17. Sutcu R., Altuntas I., Buyukvanli B., Akturk O., Ozturk O., Koylu H., Delibas N., 2007. The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat erythrocytes: role of vitamins E and C. Toxicol Indust Health. 23(1), 13-17.
18. Farooq A., Khan M.A., Ali A., Riaz A., 2011. Diversity of morphology and oil content of Rosa damascena landraces and related Rosa species from Pakistan. Pak J Agri Sci. 48(3), 177-183.
19. El-Mazoudy R.H., Attia A.A., 2012. Endocrine-disrupting and cytotoxic potential of anticholinesterase insecticide, diazinon in reproductive toxicity of male mice. J Hazard Mater. 209, 111-120.
20. Moshaie-Nezhad P., Hosseini S.M., Yahyapour M., Iman M., Khamesipoure A., 2019. Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice. J HerbMed Pharmacol. 8(1), 100-110. [Doi: 10.15171/jhp.2019.11]
21. Seo S.M., Kim J., Kang J., Koh S.H., Ahn Y.J., Kang K.S., Park I.K., 2014. Fumigant toxicity and acetylcholinesterase inhibitory activity of 4 Asteraceae plant essential oils and their constituents against Japanese termite (Reticulitermes speratus Kolbe). Pestic Biochem Physiol. 113: 55-61. DOI: 10.1016/j.pestbp.2014.06.001.
22. El-Shenawy N.S., Al-Eisa R.A., El-Salmy F., Salah O., 2009. Prophylactic effect of vitamin E against hepatotoxicity, nephrotoxicity, haematological indices and histopathology induced by diazinon insecticide in mice. Curr Zool. 55(3), 219-226.
23. Ellman G.L., Courtney K.D., Andres V., Featherstone R.M., 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacal. 7, 88-95. [DOI: 10.1016/0006-2952(61)90145-9].
24. Benzie I.F., Strain J.J., 1996. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem. 239(1), 70-76. DOI: 10.1006/abio.1996.0292.
25. Pan G., Dutta H.M., 1998. The Inhibition of Brain Acetylcholinesterase Activity of Juvenile Largemouth BassMicropterus salmoidesby Sublethal Concentrations of Diazinon. Environ Res. 79(2), 133-137. DOI: 10.1006/enrs.1998.3868.
26. Das A., Kapoor K., Sayeepriyadarshini A.T., Dikshit M., Palit G., Nath C., 2000. Immobilization stress-induced changes in brain acetylcholinesterase activity and cognitive function in mice. Pharmacol Res. 42(3), 213-217. DOI: 10.1006/phrs.2000.0678.
27. Shah M.D., Iqbal M., 2010. Diazinon-induced oxidative stress and renal dysfunction in rats. Food Chem Toxicol. 48(12), 3345-3353. DOI: 10.1016/j.fct.2010.09.003.
28. Yasa N., Masoumi F., Rouhani R.S., Haji A.A., 2009. Chemical composition and antioxidant activity of the extract and essential oil of Rosa damascena from Iran, population of Guilan. DARU. 17(3), 175-180.
29. Akram M., Riaz M., Munir N., Akhter N., Zafar S., Jabeen F., Said Khan F., 2010. Chemical constituents, experimental and clinical pharmacology of Rosa damascena: a literature review. J Pharm Pharmacol. 72(2), 161-174. DOI: 10.1111/jphp.13185.
30. Kim Y.H., Choi K.S., 2015. Effect of the Erigeron annuus in vitro antioxidant properties and extract on serum lipid in mice. Korean J Food Nutr. 28(3), 387-395. DOI: 10.1016/j.jep.2007.12.010.
31. Dundaroz M.R., Turkbay T., Akay C., Sarici S.U., Aydin A., Denli M., Gokcay E., 2003. Antioxidant enzymes and lipid peroxidation in adolescents with inhalant abuse. Turk J Pediatr Dis. 45(1), 43-45. Doi:10.1016/S0923-1811(02)00015-4.