Insights into random mutagenesis techniques to enhance biomolecule production in microalgae: Implications for economically viable bioprocesses

International Aquatic Research

مقاله 1، دوره 15، شماره 2، شهریور 2023، صفحه 85-102   

نوع مقاله: Review

شناسه دیجیتال (DOI): 10.22034/iar.2023.1982761.1419

نویسندگان

Wael A Fathy^{* 1}؛ Natascha Techen²؛ Khaled Elsayed¹؛ Ehab Essawy³؛ Eman Tawfik⁴؛ Mohamed Sayed Abdelhameed¹؛ Ola Hammouda¹؛ Samir A. Ross⁵

¹Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62511, Egypt

²National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, 38677, MS, United States

³Biochemistry Division, Chemistry Department, Faculty of Science, Helwan University, Helwan, 11795, Egypt

⁴Botany and Microbiology Department, Faculty of Science, Helwan University, Helwan, 11795, Egypt

⁵National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, 38677, MS, United States; Division of Pharmacognosy, Department of BioMolecular Sciences, School of Pharmacy, University of Mississippi, 38677, MS, United States

چکیده

Microalgae, as a diverse photosynthetic group of microorganisms with substantial ecological significance, have enormous potential for use in the food, medicine, and energy industries. However, current limitations in cost-effective production restrict their ubiquitous use. The purpose of this comprehensive mini-review is to investigate the impact of random mutagenesis techniques on microalgae and their biomolecule content, with the intention of improving the productivity and sustainability of cell factories for economically viable bioprocesses. Moreover, due to their simplicity and ease of cultivation in laboratory settings, microalgae serve as valuable model organisms for numerous scientific studies. This study investigates the effects of chemical and physical mutagens on microalgae in order to generate a heterogeneous microalgal population with advantageous traits such as increased lipids, proteins, and carotenoids, accelerated development, and enhanced nutrient absorption. This study findings will provide valuable insights into the manipulation of microalgae to increase biomolecule production and release their potential for a variety of applications.

کلیدواژه‌ها

Microalgae؛ Random mutagenesis؛ Chemical mutagens؛ Physical mutagens؛ Strain development؛ Microalgal biotechnology