Study of oxidation coupling of thiols to disulfides with Tripropylammonium fluorochromate (VI) (TriPAFC) in convenient and microwave conditions

Journal of Chemical Reactivity and Synthesis

دوره 13، شماره 2، شهریور 2023، صفحه 93-99   

نوع مقاله: Research Article

نویسندگان

Mohammad hosein farjam^{* 1}؛ Amal Berisam²

¹Department of Chemistry, Firoozabad Branch, Islamic Azad University, Firoozabad, Iran

²Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

چکیده

Tripropylammonium fluorochromate is an efficient and new reagent, which prepares easily and oxidizes thiols to the corresponding disulfides quickly. The reactions perform cleanly and controlled to stop at the disulfide stage without over-oxidation side products. Coupling of thiols to their corresponding disulfides studied in solution at room temperature and in solution under microwave radiation. The easy procedure, simple work-up, short reaction times, and excellent yields are another advantages of this reagent.

کلیدواژه‌ها

Thiol؛ Oxidation؛ Disulfide؛ Tripropylammonium fluorochromate؛ Solution؛ Microwave Irradiation