Simulation of Drug Release in Expanding Hydrogels Containing Chitosan and Gelatin

Journal of Chemical Health Risks

دوره 13، شماره 3، آذر 2023، صفحه 557-564   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.22034/jchr.2023.1982536.1709

نویسندگان

Thair Aljawahiry^{* 1}؛ Mohaned Adil²؛ Mohammed Abdulkadhim Sayah³؛ Abed J. Kadhim⁴؛ Mazin Abdullateef Alzubaidi⁵؛ Ahmed S. Abed⁶؛ Naseer Mehdi Mohammed⁷

¹College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq

²College of Pharmacy, Al-Farahidi University, Baghdad, Iraq

³Al-Manara College for Medical Sciences, Maysan, Iraq

⁴Al-Nisour University College, Baghdad, Iraq

⁵Department of Anesthesia, Al-Mustaqbal University, Babylon, Iraq

⁶Hilla University College, Babylon, Iraq, Department of Prosthetic Dental Technology, Iraq

⁷Mazaya University College, Nasiriyah, Iraq

چکیده

Utilizing mathematical modeling of drug release is one method for accelerating the rate of drug diffusion and penetration in hydrogel-based systems. This method facilitates a greater comprehension of drug control mechanisms and their release. Hydrogels are expanding biomaterials that necessitate regulation for use in drug release. The current study's objective is to model drug release in swelling hydrogels containing combinations of chitosan and gelatin polymers; with the aid of this simulation, the release time and concentration of the drug can be predicted. This modeling examined changes in the concentration of drugs in various hydrogels. For this simulation, the governing equations of the drug release system in Python and the numerical solution method were utilized to determine the drug release mechanism in the hydrogel. Then, the graphs of the changes in drug concentration in each hydrogel were examined to evaluate the performance of hydrogels in drug release. Observations revealed that the swelling rate of the hydrogel increases as the concentration of chitosan relative to gelatin in the hydrogel composition rises and that the drug release rate in hydrogels with more significant swelling was also accelerated. Compared to Cs-Gel (1:4) hydrogel, the drug release time in Cs-Gel (4:1), Cs-Gel (3:2), Cs-Gel (2.5:2.5) and Cs-Gel (2:3) hydrogels decreased by 52, 44, 37, and 18%, respectively. In hydrogels with a high swelling rate, the drug concentration decreased rapidly, whereas in hydrogels with a low swelling rate, the duration of drug release increased. This is due to the significance of mass transfer via mass movement and inflation rate.

کلیدواژه‌ها

Drug release؛ Expanding hydrogels, Chitosan؛ Gelatin

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