Synthesis and characterization of Poly(2-oxazoline)–Cefixime conjugates based surface-attached thin film of non-fouling hydrogels

International Journal of Bio-Inorganic Hybrid Nanomaterials

دوره 11، شماره 3، مهر 2022، صفحه 119-126   

نوع مقاله: Research Paper

چکیده

CDDS controlled drug release systems are a new tool to release drugs in the human body and have found many applications in the field of pharmaceutical science and technology. Therefore, the main goal of the present research is to use the surface thin layer attached to polyoxazoline from non-precipitating hydrogels for the release of Cefixime antibiotic. In this study, poly(2-ethyl-2-oxazoline) (PEOXA) chains containing 11 mole percent of benzophenone molecules were synthesized to form a hydrogel polymer network on the substrate. Important variables for the production of hydrogel film with high gel content and stability, such as heat treatment to remove the solvent, UV wavelength (which determines the radiation energy) and energy input dose and their effect on the gel content were investigated. The AFM morphology image showed a homogeneous polymer film with an average roughness of 30 nm. Cefixime is often taken every 12 hours, of which 6 hours are spent releasing the drug, and the next 6 hours are related to its effectiveness. Examining the in vitro release of Cefixime on the hydrogel substrate showed that the synthesized hydrogel has suitable properties for Cefixime drug release.

کلیدواژه‌ها

Cefixime؛ Drug release؛ Hydrogel؛ Surface fouling؛ Poly(2-oxazoline)؛ Thin film