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Zhang, Yujie, Yao, Yali, Tao, Ling, Du, Tao, Jia, Binbin, Zhou, Mi, Zhang, Zhen. (1401). Comparison of therapeutic effect and safety between warfarin anticoagulation and left atrial appendage occlusion in non valvular atrial fibrillation. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, (), -.
Yujie Zhang; Yali Yao; Ling Tao; Tao Du; Binbin Jia; Mi Zhou; Zhen Zhang. "Comparison of therapeutic effect and safety between warfarin anticoagulation and left atrial appendage occlusion in non valvular atrial fibrillation". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, , , 1401, -.
Zhang, Yujie, Yao, Yali, Tao, Ling, Du, Tao, Jia, Binbin, Zhou, Mi, Zhang, Zhen. (1401). 'Comparison of therapeutic effect and safety between warfarin anticoagulation and left atrial appendage occlusion in non valvular atrial fibrillation', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, (), pp. -.
Zhang, Yujie, Yao, Yali, Tao, Ling, Du, Tao, Jia, Binbin, Zhou, Mi, Zhang, Zhen. Comparison of therapeutic effect and safety between warfarin anticoagulation and left atrial appendage occlusion in non valvular atrial fibrillation. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1401; (): -.

Comparison of therapeutic effect and safety between warfarin anticoagulation and left atrial appendage occlusion in non valvular atrial fibrillation

International Journal of Industrial Chemistry
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 03 مرداد 1401
نوع مقاله: research article
نویسندگان
Yujie Zhang1؛ Yali Yao1؛ Ling Tao1؛ Tao Du1؛ Binbin Jia1؛ Mi Zhou* 2؛ Zhen Zhang1
1Department of Cardiology, The second people’hospital of Lanzhou, Lanzhou, Gansu 730000, China
2Department of Cardiology, The second people’hospital of Lanzhou, Lanzhou, Gansu 730000, China
چکیده
Objective To compare the therapeutic effect and safety between warfarin anticoagulation and percutaneous closure of left atrial appendage catheter (PLAATO) in non valvular atrial fibrillation (NVAF).
Methods A total of 110 NVAF patients were selected and assigned to Control group (n=55) and Observation group (n=55). The control patients were used warfarin, while the observation patients were performed PLAATO. The coagulation function, stroke and bleeding scores were compared between the two groups at different time. Left ventricular function before therapy and 1 year after therapy and adverse events during follow-up were compared between the two groups.
Results After one month of treatment, CHA2DS2-VASC, HAS-BLED score, serum ET-1 and hs-CRP levels were lower in the PLAATO patients than warfarin patients, but serum PDGFs levels were higher than patients in the warfarin patients (P < 0.05). One month after treatment, the activated partial thromboplatin time (APTT), prothrombin time (PT), and thormbin time (TT) of the PLAATO patients was longer than that of the warfarin patients (P < 0.05), but the levels of fipinogen (FIB) in the PLAATO patients were lower than that of the warfarin patients (P < 0.05). In addition, one year after therapy, the left atrial end diastolic volume (LAEDV), left atrial end systolic volume (LAESV) and left atrial inner diameter of the two groups were significantly reduced (P < 0.05).
Conclusion Left atrial appendage (LAA) occlusion can effectively improve the cardiac function and coagulation function of NVAF patients, with lower incidence of bleeding events, stroke events and higher safety.
کلیدواژه‌ها
non valvular atrial fibrillation؛ left atrial appendage occlusion؛ Warfarin؛ clinical effect
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تعداد مشاهده مقاله: 12


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