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Shiri, Elmira, Eidi, Akram, Bigdeli, Mohammad Reza, Mortazavi, Seyed Pejman. (1402). Effect of niosomes containing saponin on hippocampus tissue damage in animal model of stroke. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 15(1), 23-34. doi: 10.22034/ijnd.2023.1994434.2247
Elmira Shiri; Akram Eidi; Mohammad Reza Bigdeli; Seyed Pejman Mortazavi. "Effect of niosomes containing saponin on hippocampus tissue damage in animal model of stroke". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 15, 1, 1402, 23-34. doi: 10.22034/ijnd.2023.1994434.2247
Shiri, Elmira, Eidi, Akram, Bigdeli, Mohammad Reza, Mortazavi, Seyed Pejman. (1402). 'Effect of niosomes containing saponin on hippocampus tissue damage in animal model of stroke', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 15(1), pp. 23-34. doi: 10.22034/ijnd.2023.1994434.2247
Shiri, Elmira, Eidi, Akram, Bigdeli, Mohammad Reza, Mortazavi, Seyed Pejman. Effect of niosomes containing saponin on hippocampus tissue damage in animal model of stroke. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1402; 15(1): 23-34. doi: 10.22034/ijnd.2023.1994434.2247

Effect of niosomes containing saponin on hippocampus tissue damage in animal model of stroke

International Journal of Nano Dimension
مقاله 2، دوره 15، شماره 1، فروردین 2024، صفحه 23-34    اصل مقاله (1.01 M)
نوع مقاله: Reasearch Paper
شناسه دیجیتال (DOI): 10.22034/ijnd.2023.1994434.2247
نویسندگان
Elmira Shiri1؛ Akram Eidi* 2؛ Mohammad Reza Bigdeli* 3؛ Seyed Pejman Mortazavi4
1PhD student in animal physiology, Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2Professor, Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
3Associate Professor, Department of Animal Sciences and Marine Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
4Associate Professor, Department of Veterinary, Science and Research Branch, Islamic Azad University, Tehran, Iran.
چکیده
Cerebral ischemia is one reason for death and loss of movement ability of people, which imposes a large and significant cost on the global health system. Niosomes, as useful tools, can increase drug delivery to the brain. The purpose of this research is to investigate the effect of niosomes containing saponin (NS) on stroke- induced damage in the hippocampus of an animal model. The physicochemical characteristics of nanocarriers, such as zeta potential, size, and release test were investigated after the fabrication of thin film method. In this study, Wistar rats were divided into five experimental groups including sham group, stroke group, stroke group with empty niosome injection, stroke group with saponin injection, and stroke group with niosome saponin injection. The study examined various aspects of ischemia including stroke volume, blood-brain barrier (BBB) damage, neurological defects, levels of inflammatory cytokines, and cellular damage in the hippocampus. The findings indicate that NS, with a size of 85.92nm, zeta potential of -34.7 mv, and an entrapment efficiency (EE%) of  85.70% effectively reduced stroke volume, cerebral edema, BBB damage, expression level of TNF-α, and NF-kB genes and inflammation in hippocampal cells. Additionally, NS improved sensory and motor performance in rats. These results demonstrate that NS can mitigate stroke-induced damage in the hippocampus of the rat model by effectively crossing the BBB.

تازه های تحقیق

 

کلیدواژه‌ها
Hippocampus؛ Niosome, Neurological Deficits, Saponin؛ Stroke
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