Antimicrobial and Anti-biofilm Effect of Samarium Oxide Nanoparticles on Pseudomonas aeruginosa Isolated from Hospital wards

Biotechnological Journal of Environmental Microbiology

دوره 1، شماره 4، فروردین 2023، صفحه 186-192   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.30495/bioem.2023.1998132.1021

نویسندگان

Hossein Zahmatkesh¹؛ Mirsasan Mirpour^{* 1}؛ Hojjatolah Zamani²؛ Behnam Rasti¹

¹Department of Microbiology, Faculty of Basic Sciences, Lahijan Branch, Islamic Azad University (IAU), Lahijan, Guilan, Iran

²Department of Biology, University of Guilan, Rasht, Iran

چکیده

The development of drug resistance, treatment ineffectiveness, and the occurrence of Pseudomonas aeruginosa infections are primarily attributed to biofilm formation and quorum sensing (QS)-dependent virulence factors. This study aimed to synthesize samarium oxide nanoparticles (Sm2O3NPs) using curcumin and evaluate their antimicrobial effects against P. aeruginosa isolated from different hospital wards. Based on TEM, XRD, and EDX analysis, the synthesized nanoparticles exhibited a cubic structure with an average size of 32.61 nm and a pure crystalline phase. The Sm2O3NPs exhibited notable antibacterial efficacy against P. aeruginosa strains. Based on the CV staining assay, sub-MIC of Sm2O3NPs inhibited the biofilm formation of P. aeruginosa strains by 16-69%. Additionally, the levels of pyocyanin in the NPs-treatment groups decreased by 29-58% compared to the control group. This research confirms the significant antibacterial potential of Sm2O3NPs, implying their potential utilization as an effective antibacterial agent against P. aeruginosa strains isolated from various hospital wards, after further characterization.

کلیدواژه‌ها

Nanoparticles؛ Samarium؛ Pseudomonas aeruginosa؛ Hospital environment؛ Biofilm