The Relationship between Cadmium Pollution, Soil Biology, and Atropa Belladonna Growth

Anthropogenic Pollution

دوره 7، شماره 2، اسفند 2023، صفحه 1-20

نوع مقاله: ORIGINAL RESEARCH PAPER

شناسه دیجیتال (DOI): 10.57647/j.jap.2023.0702.17

نویسندگان

Maria Del Carmen Delgado Laime^{* 1}؛ CESAR RUBEN CASTRO LOPEZ²؛ Roger Oswaldo Poccohuanca-Aguilar³؛ Juan-Jesús Garrido-Arismendis⁴؛ Linda-Katherine Carrillo-De la Cruz⁵

¹1. Phd of Biología Ambiental, Departmentof Ingeniería Ambiental, Universidad Nacional José María Arguedas, Andahuaylas, Peru

²Mag. Tecnicas Y Gestion Medio Ambiental, department of Ingeniería, Universidad Tecnológica de los Andes, Abancay, Perú

³3. Doctoris Scientiae, Faculty of Engineering, Academic Department of Basic Sciences, National Amazonian University of Madre de Dios, Puerto Maldonado, Peru

⁴4. Student, Academic Department of Food Industries Engineering, national frontier university, Sullana, Peru

⁵5. Academic position Student, Department Professional Academic School of Law, University Continental University, Peru

چکیده

Cadmium, a heavy metal, can have devastating effects on the activity and composition of soil organisms. This can lead to environmental pollution which can be detrimental to human health. In order to evaluate the quality of contaminated soils, microbial parameters are used. The Atropa belladonna was used in a factorial experiment to investigate the efficacy of green purification and the role of arbuscular root fungi and growth-promoting bacteria in reducing the effects of cadmium. The experiment included two factors: cadmium at four levels (0, 20, 50 and 100 mg/kg of soil) and microbial inoculation treatment at three levels (control, plant growth promoting rhizobacteria and arbuscular mycorrhizal fungi). The study found that an increase in soil cadmium pollution caused a significant increase in shoot cadmium concentration and metabolic rate. Cadmium also caused a significant decrease in shoot function, microbial biomass carbon, microbial respiration, substrate-stimulated respiration, Plant growth promoting rhizobacteria population and mycorrhizal symbiosis. However, the inoculation of microbial treatments to the soil was found to decrease the inhibition effects of cadmium on the measured indicators. Overall, the results of the study showed that using growth-promoting microorganisms can reduce the adverse effect of cadmium on plant growth and microbial indicators of soil quality in soils contaminated with cadmium. Therefore, the application of growth-promoting microorganisms represents a promising approach for the remediation of cadmium-contaminated soils, as it not only supports plant growth but also enhances the overall quality of soil ecosystems.

کلیدواژه‌ها

Atropa belladonna؛ Cadmium؛ environmental pollution؛ soil ecosystems

مراجع

Abdel-Hady E-SK and Abdel-Rahman GH (2011). Protective effect of coenzyme Q10 on cadmium-induced testicular damage in male rabbits. American-Eurasian Journal of Toxicological Sciences (AEJTS), 3(3): 153-160.

Ahmad I, Akhtar M, Zahir Z and Mitter B (2015). Organic amendments: effects on cereals growth and cadmium remediation. International journal of environmental science and technology, 12: 2919-2928.

Ahmad I, Akhtar MJ, Zahir ZA, Naveed M, Mitter B, et al. (2014). Cadmium-tolerant bacteria induce metal stress tolerance in cereals. Environmental Science and Pollution Research, 21: 11054-11065.

Ahmad P, Nabi G and Ashraf M (2011). Cadmium-induced oxidative damage in mustard [Brassica juncea (L.) Czern. & Coss.] plants can be alleviated by salicylic acid. South African journal of botany, 77(1): 36-44.

Ahmadi, S., & Ghorbanpour, S. (2021). Smart Controlling Cyanide Emissions from Surface Water Resources by Predictive Models: An integrated GA-Regression. Journal of Research in Science, Engineering and Technology, 9(01), 38-49.

Ajorlo M, Abdullah RB, Hanif AHM, Halim RA and Yusoff MK (2010). How cattle grazing influences heavy metal concentrations in tropical pasture soils. Polish Journal of Environmental Studies, 19(5): 895-902.

Angeli JK, Pereira CAC, de Oliveira Faria T, Stefanon I, Padilha AS, et al. (2013). Cadmium exposure induces vascular injury due to endothelial oxidative stress: the role of local angiotensin II and COX-2. Free radical biology and medicine, 65: 838-848.

Ardakani, S. S., Heydari, A., Khorasani, N., & Arjmandi, R. (2010). Development of new bioformulations of Pseudomonas fluorescens and evaluation of these products against damping-off of cotton seedlings. Journal of Plant Pathology, 83-88.‏

Asif, M. A. (2018). A theoretical study of the size effect of carbon nanotubes on the removal of water chemical contaminants. Journal of Research in Science, Engineering and Technology, 6(04), 21-27.

Authority EFS (2012). Cadmium dietary exposure in the European population. EFSA Journal, 10(1): 2551.

Awan SA, Ilyas N, Khan I, Raza MA, Rehman AU, et al. (2020). Bacillus siamensis reduces cadmium accumulation and improves growth and antioxidant defense system in two wheat (Triticum aestivum L.) varieties. Plants, 9(7): 878.

Bashir S, Zhu J, Fu Q and Hu H (2018). Cadmium mobility, uptake and anti-oxidative response of water spinach (Ipomoea aquatic) under rice straw biochar, zeolite and rock phosphate as amendments. Chemosphere, 194: 579-587.

Bigalke M, Ulrich A, Rehmus A and Keller A (2017). Accumulation of cadmium and uranium in arable soils in Switzerland. Environmental pollution, 221: 85-93.

Brzóska MM, Rogalska J, Roszczenko A, Galazyn-Sidorczuk M and Tomczyk M (2016). The mechanism of the osteoprotective action of a polyphenol-rich Aronia melanocarpa extract during chronic exposure to cadmium is mediated by the oxidative defense system. Planta medica, 82(07): 621-631.

Buekers J, Maes A and Smolders E (2007). Fixation of cadmium, copper, nickel and zinc in soil: kinetics, mechanisms and its effect on metal bioavailability.

Chellaiah ER (2018). Cadmium (heavy metals) bioremediation by Pseudomonas aeruginosa: a minireview. Applied water science, 8(6): 154.

Chen T, Zhou Z, Han R, Meng R, Wang H, et al. (2015). Adsorption of cadmium by biochar derived from municipal sewage sludge: impact factors and adsorption mechanism. Chemosphere, 134: 286-293.

Cormet-Boyaka E, Jolivette K, Bonnegarde-Bernard A, Rennolds J, Hassan F, et al. (2012). An NF-κB–independent and Erk1/2-dependent mechanism controls CXCL8/IL-8 responses of airway epithelial cells to cadmium. Toxicological Sciences, 125(2): 418-429.

Demenesku J, Mirkov I, Ninkov M, Aleksandrov AP, Zolotarevski L, et al. (2014). Acute cadmium administration to rats exerts both immunosuppressive and proinflammatory effects in spleen. Toxicology, 326: 96-108.

Ding Y, Liu Y, Liu S, Li Z, Tan X, et al. (2016). Biochar to improve soil fertility. A review. Agronomy for sustainable development, 36: 1-18.

Djokic J, Popov Aleksandrov A, Ninkov M, Mirkov I, Zolotarevski L, et al. (2015). Cadmium administration affects circulatory mononuclear cells in rats. Journal of immunotoxicology, 12(2): 115-123.

El‐Missiry M and Shalaby F (2000). Role of β‐carotene in ameliorating the cadmium‐induced oxidative stress in rat brain and testis. Journal of biochemical and molecular toxicology, 14(5): 238-243.

Elouear Z, Bouhamed F, Boujelben N and Bouzid J (2016). Application of sheep manure and potassium fertilizer to contaminated soil and its effect on zinc, cadmium and lead accumulation by alfalfa plants. Sustainable Environment Research, 26(3): 131-135.

Fazeli M, Hassanzadeh P and Alaei S (2011). Cadmium chloride exhibits a profound toxic effect on bacterial microflora of the mice gastrointestinal tract. Human & experimental toxicology, 30(2): 152-159.

Fu M, Ren Z, Liu J, He Y, Liu C, et al. (2023). Association between cadmium exposure and the risk of cardiovascular outcomes: a meta-analysis. Human and Ecological Risk Assessment: An International Journal. 1-18.

Gao M, Zhou J, Liu H, Zhang W, Hu Y, et al. (2018). Foliar spraying with silicon and selenium reduces cadmium uptake and mitigates cadmium toxicity in rice. Science of the Total Environment, 631: 1100-1108.

Genchi G, Carocci A, Lauria G, Sinicropi MS and Catalano A (2020a). Nickel: Human health and environmental toxicology. International journal of environmental research and public health, 17(3): 679.

Genchi G, Sinicropi MS, Lauria G, Carocci A and Catalano A (2020b). The effects of cadmium toxicity. International journal of environmental research and public health, 17(11): 3782.

Go Y-M, Orr M and Jones DP (2013). Increased nuclear thioredoxin-1 potentiates cadmium-induced cytotoxicity. Toxicological Sciences, 131(1): 84-94.

Gray CW, Chrystal JM, Monaghan RM and Cavanagh J-A (2017). Subsurface cadmium loss from a stony soil—effect of cow urine application. Environmental Science and Pollution Research, 24: 12494-12500.

Guo J, Islam MA, Lin H, Ji C, Duan Y, et al. (2018). Genome-wide identification of cyclic nucleotide-gated ion channel gene family in wheat and functional analyses of TaCNGC14 and TaCNGC16. Frontiers in Plant Science, 9: 18.

Guo S-N, Zheng J-L, Yuan S-S, Zhu Q-L and Wu C-W (2017). Immunosuppressive effects and associated compensatory responses in zebrafish after full life-cycle exposure to environmentally relevant concentrations of cadmium. Aquatic Toxicology, 188: 64-71.

Han Y-L, Sheng Z, Liu G-D, Long L-L, Wang Y-F, et al. (2015). Cloning, characterization and cadmium inducibility of metallothionein in the testes of the mudskipper Boleophthalmus pectinirostris. Ecotoxicology and Environmental Safety, 119: 1-8.

Hartwig A (2010). Mechanisms in cadmium-induced carcinogenicity: recent insights. Biometals, 23: 951-960.

Hasan MK, Ahammed GJ, Sun S, Li M, Yin H, et al. (2019). Melatonin inhibits cadmium translocation and enhances plant tolerance by regulating sulfur uptake and assimilation in Solanum lycopersicum L. Journal of Agricultural and Food Chemistry, 67(38): 10563-10576.

Hasan SA, Ali B, Hayat S and Ahmad A (2007). Cadmium-induced changes in the growth and carbonic anhydrase activity of chickpea. Turkish Journal of Biology, 31(3): 137-140.

Hasan SA, Fariduddin Q, Ali B, Hayat S and Ahmad A (2009). Cadmium: toxicity and tolerance in plants. J Environ Biol, 30(2): 165-174.

Hassan Z and Aarts MG (2011). Opportunities and feasibilities for biotechnological improvement of Zn, Cd or Ni tolerance and accumulation in plants. Environmental and Experimental Botany, 72(1): 53-63.

Henning SM, Wang P, Said JW, Huang M, Grogan T, et al. (2015). Randomized clinical trial of brewed green and black tea in men with prostate cancer prior to prostatectomy. The Prostate, 75(5): 550-559.

Huang Y-Y, Xia M-Z, Wang H, Liu X-J, Hu Y-F, et al. (2014). Cadmium selectively induces MIP-2 and COX-2 through PTEN-mediated Akt activation in RAW264. 7 cells. Toxicological Sciences, 138(2): 310-321.

Imam SA, Rajpoot IK, Gajjar B and Sachdeva A (2016). Comparative study of heavy metal bioremediation in soil by Bacillus subtilis and Saccharomyces cerevisiae. Indian J. Sci. Technol, 9(47): 1-7.

Ismael MA, Elyamine AM, Moussa MG, Cai M, Zhao X, et al. (2019). Cadmium in plants: uptake, toxicity, and its interactions with selenium fertilizers. Metallomics, 11(2): 255-277.

Jiang G, Xu L, Song S, Zhu C, Wu Q, et al. (2008). Effects of long-term low-dose cadmium exposure on genomic DNA methylation in human embryo lung fibroblast cells. Toxicology, 244(1): 49-55.

Julin B, Wolk A, Bergkvist L, Bottai M and Åkesson A (2012). Dietary cadmium exposure and risk of postmenopausal breast cancer: a population-based prospective cohort study. Cancer research, 72(6): 1459-1466.

Júnior LB, Macedo G, Duarte M, Silva E and Lobato A (2003). Biosorption of cadmium using the fungus Aspergillus niger. Brazilian Journal of Chemical Engineering, 20(3): 229-240.

Khandare RV and Govindwar SP (2015). Phytoremediation of textile dyes and effluents: Current scenario and future prospects. Biotechnology advances, 33(8): 1697-1714.

Khaokaew S and Landrot G (2015). A field-scale study of cadmium phytoremediation in a contaminated agricultural soil at Mae Sot District, Tak Province, Thailand:(1) Determination of Cd-hyperaccumulating plants. Chemosphere, 138: 883-887.

Kim K-R, Owens G and Naidu R (2009). Heavy metal distribution, bioaccessibility, and phytoavailability in long-term contaminated soils from Lake Macquarie, Australia. Soil Research, 47(2): 166-176.

Kim K, Melough MM, Vance TM, Noh H, Koo SI, et al. (2018). Dietary cadmium intake and sources in the US. Nutrients, 11(1): 2.

Kim M and Wolt JD (2008). Cadmium exposure in the South Korean population: Implications of input assumptions for deterministic dietary assessment. Human and Ecological Risk Assessment, 14(4): 835-850.

Krantev A, Yordanova R, Janda T, Szalai G and Popova L (2008). Treatment with salicylic acid decreases the effect of cadmium on photosynthesis in maize plants. Journal of Plant Physiology, 165(9): 920-931.

Ku Y, Wu M-H and Shen Y-S (2002). A study on the cadmium removal from aqueous solutions by zinc cementation. Separation Science and Technology, 37(3): 571-590.

Kubier A and Pichler T (2019). Cadmium in groundwater− A synopsis based on a large hydrogeochemical data set. Science of the Total Environment, 689: 831-842.

Kubier A, Wilkin RT and Pichler T (2019). Cadmium in soils and groundwater: a review. Applied Geochemistry, 108: 104388.

Kuiper I, Lagendijk EL, Bloemberg GV and Lugtenberg BJ (2004). Rhizoremediation: a beneficial plant-microbe interaction. Molecular plant-microbe interactions, 17(1): 6-15.

Kundu S, Sengupta S and Bhattacharyya A (2011). EGFR upregulates inflammatory and proliferative responses in human lung adenocarcinoma cell line (A549), induced by lower dose of cadmium chloride. Inhalation toxicology, 23(6): 339-348.

Lakshmi B, Sudhakar M and Aparna M (2014). Protective effect of black grapes on cadmium induced hepatotoxicity in rats. World Journal of Pharmaceutical Sciences. 276-282.

Lata S, Kaur HP and Mishra T (2019). Cadmium bioremediation: a review. Int. J. Pharm. Sci. Res, 10: 4120-4128.

Li Q, Wang G, Wang Y, Yang D, Guan C, et al. (2019). Foliar application of salicylic acid alleviate the cadmium toxicity by modulation the reactive oxygen species in potato. Ecotoxicology and Environmental Safety, 172: 317-325.

Li Z, Wu L, Luo Y and Christie P (2018). Changes in metal mobility assessed by EDTA kinetic extraction in three polluted soils after repeated phytoremediation using a cadmium/zinc hyperaccumulator. Chemosphere, 194: 432-440.

Liu H, Yuan M, Tan S, Yang X, Lan Z, et al. (2015). Enhancement of arbuscular mycorrhizal fungus (Glomus versiforme) on the growth and Cd uptake by Cd-hyperaccumulator Solanum nigrum. Applied Soil Ecology, 89: 44-49.

Liu L, Li J, Yue F, Yan X, Wang F, et al. (2018). Effects of arbuscular mycorrhizal inoculation and biochar amendment on maize growth, cadmium uptake and soil cadmium speciation in Cd-contaminated soil. Chemosphere, 194: 495-503.

Liu Z, Cai L, Liu Y, Chen W and Wang Q (2019). Association between prenatal cadmium exposure and cognitive development of offspring: A systematic review. Environmental pollution, 254: 113081.

Lopez F and Barclay G (2017). Plant anatomy and physiology. Pharmacognosy. Elsevier, pp.45-60.

Lu L-l, Tian S-k, Yang X-e, Li T-q and He Z-l (2009). Cadmium uptake and xylem loading are active processes in the hyperaccumulator Sedum alfredii. Journal of Plant Physiology, 166(6): 579-587.

Lv Y, Wang P, Huang R, Liang X, Wang P, et al. (2017). Cadmium exposure and osteoporosis: A population‐based study and benchmark dose estimation in southern China. Journal of Bone and Mineral Research, 32(10): 1990-2000.

M Brzóska M, Borowska S and Tomczyk M (2016). Antioxidants as a potential preventive and therapeutic strategy for cadmium. Current drug targets, 17(12): 1350-1384.

M Brzoska M, Galazyn-Sidorczuk M, Jurczuk M and Tomczyk M (2015). Protective effect of Aronia melanocarpa polyphenols on cadmium accumulation in the body: A study in a rat model of human exposure to this metal. Current drug targets, 16(13): 1470-1487.

Mahajan P and Kaushal J (2018). Role of phytoremediation in reducing cadmium toxicity in soil and water. Journal of toxicology, 2018.

Marlina, E., Purwanto, P., & Sudarno, S. (2022). Decolorization of industrial wastewater using electrochemical peroxidation process. Journal of Electrochemical Science and Engineering, 12(2), 373-382.

Mekwilai, W. ., Sirichana, W., Thawanaphong, S. ., Kawkitinarong, K. ., & Taneepanichskul, N. . (2023). Assessing the association between daily self-reported health symptoms and mental health among respiratory patients during high-pollution period in Thailand. International Journal of Innovative Research and Scientific Studies, 6(3), 626–632.

Mezynska M and Brzóska MM (2018). Environmental exposure to cadmium—A risk for health of the general population in industrialized countries and preventive strategies. Environmental Science and Pollution Research, 25: 3211-3232.

Miyahara T, Katoh T, Watanabe M, Mikami Y, Uchida S, et al. (2004). Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells. Toxicology, 200(2-3): 159-167.

Muthumanickam, K., & Saravanathamizhan, R. (2021). Electrochemical treatment of dye wastewater using nickel foam electrode. Journal of Electrochemical Science and Engineering, 11(3), 209-215.

Nath S, Deb B, Sharma I and Pandey P (2014). Role of cadmium and lead tolerant pseudomonas aeruginosa in seedling germination of rice (Oryza sativa L.). J Environ Anal Toxicol, 4(221): 2161-0525.

Nazar R, Iqbal N, Masood A, Khan MIR, Syeed S, et al. (2012). Cadmium toxicity in plants and role of mineral nutrients in its alleviation.

NING C-c, GAO P-d, WANG B-q, LIN W-p, JIANG N-h, et al. (2017). Impacts of chemical fertilizer reduction and organic amendments supplementation on soil nutrient, enzyme activity and heavy metal content. Journal of Integrative Agriculture, 16(8): 1819-1831.

Ninkov M, Aleksandrov AP, Demenesku J, Mirkov I, Mileusnic D, et al. (2015). Toxicity of oral cadmium intake: Impact on gut immunity. Toxicology Letters, 237(2): 89-99.

Oh C-M, Oh I-H, Lee J-K, Park YH, Choe B-K, et al. (2014). Blood cadmium levels are associated with a decline in lung function in males. Environmental research, 132: 119-125.

Parthipan P, Preetham E, Machuca LL, Rahman PK, Murugan K, et al. (2017). Biosurfactant and degradative enzymes mediated crude oil degradation by bacterium Bacillus subtilis A1. Frontiers in microbiology, 8: 193.

Person RJ, Tokar EJ, Xu Y, Orihuela R, Ngalame NNO, et al. (2013). Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells. Toxicology and applied pharmacology, 273(2): 281-288.

Phuagkhaopong S, Ospondpant D, Kasemsuk T, Sibmooh N, Soodvilai S, et al. (2017). Cadmium-induced IL-6 and IL-8 expression and release from astrocytes are mediated by MAPK and NF-κB pathways. Neurotoxicology, 60: 82-91.

Popova LP, Maslenkova LT, Ivanova A and Stoinova Z (2012). Role of salicylic acid in alleviating heavy metal stress. Environmental adaptations and stress tolerance of plants in the era of climate change. 447-466.

Prabu S and Shagirtha K (2019). Cadmium and apoptosis: a molecular approach. Res. Rev. J. Toxicol, 6: 8-17.

Radhakrishnan R, Hashem A and Abd_Allah EF (2017). Bacillus: A biological tool for crop improvement through bio-molecular changes in adverse environments. Frontiers in physiology, 8: 667.

Radziemska M, Vaverková MD and Baryła A (2017). Phytostabilization—management strategy for stabilizing trace elements in contaminated soils. International journal of environmental research and public health, 14(9): 958.

Rafiee, P. (2020). Comparison Coagulant Performance of Chloroferric and Polyelectrolyte (LT25) in Removing Organic Materials Turbidity in Raw Water Resources of Ardabil Treatment Plant. Journal of Research in Science, Engineering and Technology, 8(1), 7-13.

Rao K, Mohapatra M, Anand S and Venkateswarlu P (2010). Review on cadmium removal from aqueous solutions. International journal of engineering, science and technology, 2(7).

Razzuoli E, Mignone G, Lazzara F, Vencia W, Ferraris M, et al. (2018). Impact of cadmium exposure on swine enterocytes. Toxicology Letters, 287: 92-99.

Rogalska J, Pilat-Marcinkiewicz B and Brzóska MM (2011). Protective effect of zinc against cadmium hepatotoxicity depends on this bioelement intake and level of cadmium exposure: a study in a rat model. Chemico-biological interactions, 193(3): 191-203.

Sahu A, Mandal A, Thakur J, Manna M and Rao AS (2012). Exploring bioaccumulation efficacy of Trichoderma viride: an alternative bioremediation of cadmium and lead. National Academy Science Letters, 35: 299-302.

Satarug S, Swaddiwudhipong W, Ruangyuttikarn W, Nishijo M and Ruiz P (2013). Modeling cadmium exposures in low-and high-exposure areas in Thailand. Environmental health perspectives, 121(5): 531-536.

Shaaban M, Van Zwieten L, Bashir S, Younas A, Núñez-Delgado A, et al. (2018). A concise review of biochar application to agricultural soils to improve soil conditions and fight pollution. Journal of environmental management, 228: 429-440.

Shahid M, Pourrut B, Dumat C, Nadeem M, Aslam M, et al. (2014). Heavy-metal-induced reactive oxygen species: phytotoxicity and physicochemical changes in plants. Reviews of Environmental Contamination and Toxicology Volume 232. 1-44.

Sharma A, Sidhu GPS, Araniti F, Bali AS, Shahzad B, et al. (2020). The role of salicylic acid in plants exposed to heavy metals. Molecules, 25(3): 540.

Singh HP, Batish DR, Kaur G, Arora K and Kohli RK (2008). Nitric oxide (as sodium nitroprusside) supplementation ameliorates Cd toxicity in hydroponically grown wheat roots. Environmental and Experimental Botany, 63(1-3): 158-167.

Six L and Smolders E (2014). Future trends in soil cadmium concentration under current cadmium fluxes to European agricultural soils. Science of the Total Environment, 485: 319-328.

Sohail MI, Arif M, Rauf A, Rizwan M, Ali S, et al. (2019). Organic manures for cadmium tolerance and remediation. Cadmium Tolerance in Plants. Elsevier, pp.19-67.

Song SY, Bae CH, Choi YS and Kim YD (2016) Cadmium induces mucin 8 expression via Toll‐like receptor 4–mediated extracellular signal related kinase 1/2 and p38 mitogen‐activated protein kinase in human airway epithelial cells. International Forum of Allergy & Rhinology. Wiley Online Library, 638-645.

Song Y, Jin L and Wang X (2017). Cadmium absorption and transportation pathways in plants. International journal of phytoremediation, 19(2): 133-141.

Tan, P.-L. ., Soo, K. Q.-S. ., Khor, Y.-P. ., Abas, F. ., & Tan, C.-P. (2022). Enzyme-Assisted Water Extraction Optimization, Antioxidant Capacity and Phenolic Profiling of Extracts from Garcinia Mangostana Linn . Journal of Food Technology Research, 9(2), 135–149.

Theron AJ, Tintinger GR and Anderson R (2012). Harmful interactions of non-essential heavy metals with cells of the innate immune system.

Tran TA and Popova LP (2013). Functions and toxicity of cadmium in plants: recent advances and future prospects. Turkish journal of Botany, 37(1): 1-13.

UNEP (2010) Final review of scientific information on cadmium. United Nations Environment Programme, Chemicals Branch, Division of ….

Wang B, Liu L, Gao Y and Chen J (2009). Improved phytoremediation of oilseed rape (Brassica napus) by Trichoderma mutant constructed by restriction enzyme-mediated integration (REMI) in cadmium polluted soil. Chemosphere, 74(10): 1400-1403.

Wang F, Liu X, Shi Z, Tong R, Adams CA, et al. (2016). Arbuscular mycorrhizae alleviate negative effects of zinc oxide nanoparticle and zinc accumulation in maize plants–a soil microcosm experiment. Chemosphere, 147: 88-97.

Wang H, Feng L and Chen Y-g (2012). Advances in biochar production from wastes and its applications. Chemical Industry and Engineering Progress, 31(4): 907-914.

Wang M, Yang Y and Chen W (2018). Manganese, zinc, and pH affect cadmium accumulation in rice grain under field conditions in southern China. journal of environmental quality, 47(2): 306-311.

Wang M and Zhou Q (2005). Single and joint toxicity of chlorimuron-ethyl, cadmium, and copper acting on wheat Triticum aestivum. Ecotoxicology and Environmental Safety, 60(2): 169-175.

Wei Z, Zhao X, Zhu C, Xi B, Zhao Y, et al. (2014). Assessment of humification degree of dissolved organic matter from different composts using fluorescence spectroscopy technology. Chemosphere, 95: 261-267.

Wu Z, Liu S, Zhao J, Wang F, Du Y, et al. (2017). Comparative responses to silicon and selenium in relation to antioxidant enzyme system and the glutathione-ascorbate cycle in flowering Chinese cabbage (Brassica campestris L. ssp. chinensis var. utilis) under cadmium stress. Environmental and Experimental Botany, 133: 1-11.

Xie D, Li Y, Liu Z and Chen Q (2019). Inhibitory effect of cadmium exposure on digestive activity, antioxidant capacity and immune defense in the intestine of yellow catfish (Pelteobagrus fulvidraco). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 222: 65-73.

Xie M, Jarrett BA, Da Silva-Cadoux C, Fetters KJ, Burton Jr GA, et al. (2015). Coupled effects of hydrodynamics and biogeochemistry on Zn mobility and speciation in highly contaminated sediments. Environmental Science & Technology, 49(9): 5346-5353.

Yaghoubian Y, Siadat SA, Moradi Telavat MR, Pirdashti H and Yaghoubian I (2019). Bio-removal of cadmium from aqueous solutions by filamentous fungi: Trichoderma spp. and Piriformospora indica. Environmental Science and Pollution Research, 26: 7863-7872.

Yuan P, Wang J, Pan Y, Shen B and Wu C (2019). Review of biochar for the management of contaminated soil: Preparation, application and prospect. Science of the Total Environment, 659: 473-490.

Yuan X, Wang J, Shang Ye and Sun B (2014). Health risk assessment of cadmium via dietary intake by adults in China. Journal of the Science of Food and Agriculture, 94(2): 373-380.

Zhai Q, Wang G, Zhao J, Liu X, Narbad A, et al. (2014). Protective effects of Lactobacillus plantarum CCFM8610 against chronic cadmium toxicity in mice indicate routes of protection besides intestinal sequestration. Applied and Environmental Microbiology, 80(13): 4063-4071.

Zhai Q, Yin R, Yu L, Wang G, Tian F, et al. (2015). Screening of lactic acid bacteria with potential protective effects against cadmium toxicity. Food Control, 54: 23-30.

Zhang F, Liu M, Li Y, Che Y and Xiao Y (2019). Effects of arbuscular mycorrhizal fungi, biochar and cadmium on the yield and element uptake of Medicago sativa. Science of the Total Environment, 655: 1150-1158.

Zhang H, Dang Z, Zheng L and Yi X (2009). Remediation of soil co-contaminated with pyrene and cadmium by growing maize (Zea mays L.). International Journal of Environmental Science & Technology, 6: 249-258.

Zhang J, Martinoia E and Lee Y (2018). Vacuolar transporters for cadmium and arsenic in plants and their applications in phytoremediation and crop development. Plant and Cell Physiology, 59(7): 1317-1325.

Zhang R-R, Liu Y, Xue W-L, Chen R-X, Du S-T, et al. (2016). Slow-release nitrogen fertilizers can improve yield and reduce Cd concentration in pakchoi (Brassica chinensis L.) grown in Cd-contaminated soil. Environmental Science and Pollution Research, 23: 25074-25083.

Zhang Y, Xu X, Sun D, Cao J, Zhang Y, et al. (2017). Alteration of the number and percentage of innate immune cells in preschool children from an e-waste recycling area. Ecotoxicology and Environmental Safety, 145: 615-622.

Zhao D, Wang P and Zhao F-J (2023). Dietary cadmium exposure, risks to human health and mitigation strategies. Critical Reviews in Environmental Science and Technology, 53(8): 939-963.

Zhao FY, Han MM, Zhang SY, Wang K, Zhang CR, et al. (2012). Hydrogen peroxide‐mediated growth of the root system occurs via auxin signaling modification and variations in the expression of cell‐cycle genes in rice seedlings exposed to cadmium stress. Journal of integrative plant biology, 54(12): 991-1006.

Zhao X, Shao Y, Ma L, Shang X, Zhao Y, et al. (2022). Exposure to Lead and Cadmium in the Sixth Total Diet Study—China, 2016− 2019. China CDC Weekly, 4(9): 176.

Zhou Z, Liu H, Wang C, Lu Q, Huang Q, et al. (2015). Long non-coding RNAs as novel expression signatures modulate DNA damage and repair in cadmium toxicology. Scientific reports, 5(1): 15293.

Zhu C, Wen H, Zhang Y, Fan H, Fu S, et al. (2013). Characteristics of Cd isotopic compositions and their genetic significance in the lead-zinc deposits of SW China. Science China Earth Sciences, 56: 2056-2065.

Zulfiqar S, Wahid A, Farooq M, Maqbool N and Arfan M (2012). Phytoremediation of soil cadmium using Chenopodium species. Pak. J. Agri. Sci, 49(4): 435-445.

Zulfiqar U, Farooq M, Hussain S, Maqsood M, Hussain M, et al. (2019). Lead toxicity in plants: Impacts and remediation. Journal of environmental management, 250: 109557.