Preparation and characterization of a dual acidic Ionic Liquid functionalized Graphene Oxide nanosheets as a Heterogeneous Catalyst for the Synthesis of pyrimido[4,5-b] quinolines in water

Iranian Journal of Catalysis

مقاله 7، دوره 13، شماره 4، اسفند 2023، صفحه 499-516   

نوع مقاله: Articles

شناسه دیجیتال (DOI): 10.30495/ijc.2023.1998276.2052

نویسندگان

Mohanad Yakdhan Saleh^{* 1}؛ Ghufran Th. Sadeek¹؛ Shakir Mahmood Saied²

¹Department of Chemistry, College of Education for pure Science, Mosul University, Ministry of High Education and Scientific Research, Mosul, Iraq

²Department of Medical Laboratory Techniques, Al-Noor University College, Iraq

چکیده

Pyrimido[4,5-b]quinolones play a significant role in medicinal chemistry owing to their various biological properties, including antihistaminic, antimalarial, antifungal, anticancer, antioxidant, antiviral, anti-microbial, and anti-inflammatory activities. A dual acidic ionic liquid anchored on graphene oxide nanosheets (GO-Si-Pr-Lysin-SO₃H) was provided and characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FT-IR). The six-step process was utilized to create this catalyst, beginning with graphite powder. This catalyst was capable to develop the one-pot and three components (6-amino-1,3-dimethyluracil, dimedone, and different aromatic aldehydes) synthesis of pyrimido[4,5-b]quinolone derivatives at moderate temperature in water as a green medium (12 derivatives). The results obtained indicated that this method could be an effective approach for synthesizing pyrimido[4,5-b]quinolones with high yields ranging from 86% to 98% in a short reaction time of 15 to 40 minutes. In addition, the pointed catalyst shows reusability and recoverability without remarkable loss of catalytic activity.

کلیدواژه‌ها

Green catalyst؛ ionic liquid؛ graphene oxide؛ pyrimido[4,5-b]quinolones؛ reusability

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