Investigating the effect of mesenchymal stem cells on airway hyper-responsiveness of asthma

Journal of Basic and Clinical Veterinary Medicine

مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 25 آذر 1402   

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.30495/jbcvm.2023.2000530.1053

نویسندگان

Kambiz Moghaddasi¹؛ Saeed Hesaraki²؛ Farnoosh Arfaee^{* 1}؛ Seyyed Shamsadin Athari^{* 3}

¹Department of Clinical Sciences, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran

²Department of Pathobiology, Faculty of Specialized Veterinary Science, Science and Research Branch, Islamic Azad University, Tehran, Iran

³Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

چکیده

Asthma is one of the main lung diseases that is identified by eosinophilic inflammation, mucus secretion, airway hyper-responsiveness (AHR) and airway obstruction. AHR is one of the important action of airways in asthma. Mesenchymal stem cells (MSCs) have regulatory effect on immune response and may be useful to the treatment of asthma. MSCs have low immunogenicity and may be safe in application. Furthermore, study effect of MSCs controlling of AHR in asthma model was done.

MSCs were isolated and used as treatment in asthmatic male BALB/c mice.

To produce asthma animal model, mice were sensitized and challenged with OVA. On days 30 and 40, to measure of AHR, Methacholine challenge test was applied to determine the Penh value. At least, AHR were recorded and analyzed.

Treatment of asthmatic mice with MSCs could control AHR in MCh challenge test and it has significant difference (p<0.05) between days 30 and 40.

MSC is almost non-immunogenic and can be used to treat asthma and control of AHR. Using of MSCs as anti-asthma treatment presents new and applicable strategy to control of AHR in asthma.

کلیدواژه‌ها

allergy؛ cell therapy؛ asthma؛ lung؛ treatment