مروری برکاربرد نانوذرات کیتوسان در درمان انواع سرطان و بررسی سمیت سلولی آنها

فصلنامه زیست شناسی جانوری

دوره 16، شماره 2، اسفند 1402، صفحه 203-218   

نوع مقاله: مقالات مروری

شناسه دیجیتال (DOI): 10.22034/ascij.2023.1989804.1505

نویسنده

الهام رستمی^*

گروه شیمی، دانشکده علوم، دانشگاه شهید چمران اهواز، اهواز، ایران

چکیده

کیتوسان یکی از مناسب‌ترین بیوپلیمرها با امکانات گسترده برای بهبود بخشیدن ویژگی‌های جدید نانو دارو و استفاده در زمینه‌های زیست­دارویی است که از کیتین دی‌استیل و آمینو‌پلی‌ساکارید ساخته شده است. ویژگی‌های متنوع دارو از جمله خاصیت کاتیونی و رهایش کنترل­شده­ به دلیل وجود گروه عاملی آمینی نوع اول در کیتوسان است. این ویژگی‌های عالی، زیست‌سازگاری، زیست‌تخریب­پذیری و ظرفیت بارگذاری، راه‌حل کارآمدی برای جلوگیری از واکنش‌های نامطلوب می‌باشند. با اصلاح نانوذرات کیتوسان که بطور رایج به عنوان حامل دارو تولید و استفاده می‌شوند، سمیت و عوارض جانبی ناشی از تجویزات کاهش داده می‌شوند. دستیابی به رسانش هدفمند دارو، با استفاده از پپتید‌ها، آنتی‌بادی­ها، آپتامر یا مولکول‌های کوچک میسر می‌شود. روش‌های ذکر شده دوز میزان استفاده از داروی لازم را کاهش می‌دهند. بعلاوه، آنها دارو را به سمت بافت هدف هدایت می‌کنند. این مقاله مروری با هدف نشان دادن اهمیت ویژگی‌های نانوذرات متصل به آنتی‌بادی، مغناطیسی، کیتوسان مزدوج حساس به pH، در انتقال هدفمند دارو انجام شد. همچنین اثر انواع این نانوذرات بر رده‌های مختلف سلول‌های سرطانی، سمیت سلولی انواع نانوذرات و  فارماکوکینتیک آنها مورد بررسی قرار گرفته است. روش گردآوری اطلاعات استفاده از پایگاه­های علمی Scopus، Elsevier و PubMed می­باشد.

کلیدواژه‌ها

انتقال هدفمند دارو؛ کیتوسان؛ نانوذرات؛ سمیت سلولی

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