Efficacy of topical application of Carvacrol, Amitraz, and combination of carvacrol-amitraz for the treatment of dogs with generalized demodicosis

Journal of Basic and Clinical Veterinary Medicine

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 02 دی 1402

نوع مقاله: Original Article

شناسه دیجیتال (DOI): 10.30495/jbcvm.2023.2002042.1056

نویسندگان

sina fereydooni¹؛ Farnoosh Arfaee^{* 2}؛ Mohammad Reza Youssefi³؛ Fatemeh zahra Gharib⁴؛ mohaddeseh abouhosseini tabari⁵

¹Department of Clinical Sciences, Science and Research branch, Islamic Azad university, Tehran, Iran

²Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

³Department of Veterinary Parasitology, Babol Branch, Islamic Azad University, Babol, Iran

⁴Department of Veterinary Clinical Sciences, Babol Branch, Islamic Azad University, Babol, Iran

⁵Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, Iran

چکیده

Canine demodicosis is an inflammatory parasitic skin disease caused by an increasing population of Demodex spp. mites. There is an urgent need for efficacious, safe, and available treatment for demodicosis. The present study aimed at evaluating the activity of Carvacrol 5%, Amitraz 0.05%, and Carvacrol-Amitraz combination on the killing of Demodex canis mites after topical pour-on use and analyzing the improvement in associated dermatologic signs. Fifteen dogs with naturally acquired generalized demodicosis were randomly allocated to 3 equal study groups. The dogs were selected from the animal shelter in Mazandaran province. Treatment groups include a pour-on solution of 50 ml of 5% Carvacrol, 50 ml of Amitraz 0.05%, and a combination of Carvacrol and Amitraz 1:1 mixture at the same concentrations. All treatment groups were checked for improvement of demodicosis. Evaluation of clinical factors consisted of mite count by skin scraping, hair re-growth, Comedones, erythema, crusts, and scales during seven-day intervals over four weeks. Mite counts had a significant decrease in all groups during the study, especially in Carvacrol 5% (P<0.05). There was no significant difference between Amitraz and Carvacrol + Amitraz on days 14, 21, and 28 (P>0.05). The highest decrease in the mite population was associated with Carvacrol 5% from day 14 up to 90% in demodicosis treatment. This clinical field study demonstrated that pour-on administration of Carvacrol 5% is highly effective in the reduction of mite numbers and improvement in associated dermatologic signs of demodicosis.

کلیدواژه‌ها

Demodicosis؛ Carvacrol؛ Amitraz؛ skin؛ pour-on