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Synthesis and Physicochemical Characterization of New Amidic Derivative of Sodium Alginate | ||
Journal of Chemical Reactivity and Synthesis | ||
دوره 13، شماره 4، اسفند 2023، صفحه 286-298 اصل مقاله (991.56 K) | ||
نوع مقاله: Research Article | ||
نویسندگان | ||
Shokouh Khodayar1؛ Mohammad Reza Shushizadeh* 2؛ Elham Tahanpesar3؛ Behzad Sharif Makhmalzadeh4؛ Haleh Sanaeishoar5 | ||
1Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. | ||
2Marine Pharmaceutical Science Research Center and Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz Iran. | ||
3Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran | ||
4Nanotechnology research center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
5Department of chemistry, Ahvaz branch, Islamic Azad university | ||
چکیده | ||
In this study, our objective was to synthesis a new derivative of alginate, a natural biocompatible, biodegradable and non-toxic biopolymer to improve the gelling mechanism. For this purpose, ethylenediamine (EDA) was coupled to sodium alginate (NaA) in an aqueous-phase reaction using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC-HCl) and N-hydroxy succinimide (NHS) as coupling reagents to synthesis ethylenediamine-grafted amphiphilic sodium alginate-amide derivative (NaA-g-EDA). Synthesized derivative showed no environmental sensitivity but the swelling percentage of hydrogels shows that hydrogels obtained from NaA-g-EDA had higher water absorption compared to non-functionalized sodium alginate. It seems that hydrogels can uptake water more than 100% of their weight but in a slow manner. This character is a perfect property for wound dressing. Biodegradable synthesized hydrogel can be decomposed into non-toxic by-products. The purity and grafting of copolymers were characterized using fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1HNMR), X-ray diffraction (XRD), and elemental analysis (CHNX). These analytical methods confirmed the structure of NaA-g-EDA. | ||
کلیدواژهها | ||
Biohydrogel؛ Sodium alginate؛ Ethylenediamine؛ Amidation reaction | ||
آمار تعداد مشاهده مقاله: 27 تعداد دریافت فایل اصل مقاله: 118 |