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Sasan Mehr, Ghazal, Honarmand Jahromy, sahar, Mahdavi-Ourtakand, Masoumeh. (1402). Identification and Antibiotics Combination Testing against Multiple-Drug Resistance Acinetobacter baumannii isolates. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 13(2), 1959-1969. doi: 10.22034/ijmcm.2023.710010
Ghazal Sasan Mehr; sahar Honarmand Jahromy; Masoumeh Mahdavi-Ourtakand. "Identification and Antibiotics Combination Testing against Multiple-Drug Resistance Acinetobacter baumannii isolates". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 13, 2, 1402, 1959-1969. doi: 10.22034/ijmcm.2023.710010
Sasan Mehr, Ghazal, Honarmand Jahromy, sahar, Mahdavi-Ourtakand, Masoumeh. (1402). 'Identification and Antibiotics Combination Testing against Multiple-Drug Resistance Acinetobacter baumannii isolates', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 13(2), pp. 1959-1969. doi: 10.22034/ijmcm.2023.710010
Sasan Mehr, Ghazal, Honarmand Jahromy, sahar, Mahdavi-Ourtakand, Masoumeh. Identification and Antibiotics Combination Testing against Multiple-Drug Resistance Acinetobacter baumannii isolates. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1402; 13(2): 1959-1969. doi: 10.22034/ijmcm.2023.710010

Identification and Antibiotics Combination Testing against Multiple-Drug Resistance Acinetobacter baumannii isolates

International Journal of Molecular and Clinical Microbiology
دوره 13، شماره 2، آذر 2023، صفحه 1959-1969    اصل مقاله (468.23 K)
نوع مقاله: Research Article
شناسه دیجیتال (DOI): 10.22034/ijmcm.2023.710010
نویسندگان
Ghazal Sasan Mehr1؛ sahar Honarmand Jahromy* 2؛ Masoumeh Mahdavi-Ourtakand3
1Department of Microbiology, School of Biological Science, Varamin- Pishva Branch, Islamic Azad University, Varamin, Iran
2Department of Microbiology, Islamic Azad University, Varamin-Pishva Branch, Iran.
3Department of Microbiology, College of Biological Sciences, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran
چکیده
The result showed the maximum resistance for imipenem (100%), meropenem (100%), cefotaxime (98.6%), and ceftazidime (98.6%), and minimum resistance for tetracycline (65.7%) and gentamicin (68.6%). The MCBT test for meropenem-gentamicin-tetracycline antibiotics demonstrated 65.6% and 6.3% of MDR Acinetobacter baumannii strains killed at high and low concentrations of antibiotics, respectively (P=0.04). Besides, 34.4% and 93.8% of MDR Acinetobacter baumannii strains lived at high and low concentrations of meropenem-gentamicin-tetracycline antibiotics, respectively, which were statistically significant (P=0.04). There was a significant relationship between the MIC of gentamicin-meropenem in the combination (Checkerboard) (P=0.0001). Antibiotic interaction effects frequencies were 6.3%, 53.1%, and 40.6% for synergy, incremental, and indifference, respectively. In this study, a significant difference was shown between the FICIs of meropenem (0.68±0.27) and gentamicin (0.003±0.003) (P=0.0001). Also, there was a significant correlation between the FICI factor and the antibiotic's antimicrobial interaction by MCBT (r=0.95, P=0.0001).
Conclusion: It seems that the combination of meropenem-gentamicin-tetracycline antibiotics had additive antibacterial effects and could be used to suppress MDR Acinetobacter baumannii isolated.
کلیدواژه‌ها
Acinetobacter baumannii؛ MCBT؛ MICI؛ Synergism؛ MDR.  
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