The potential of aromatase inhibitors in fish masculinization: a comprehensive review of applications, mechanisms and future perspectives

International Aquatic Research

مقاله 2، دوره 16، شماره 2، شهریور 2024، صفحه 113-142   

نوع مقاله: Review

شناسه دیجیتال (DOI): 10.22034/iar.2024.2008470.1624

نویسندگان

Jham Lal¹؛ Anand Vaishnav¹؛ Soibam Khogen Singh¹؛ Pradyut Biswas¹؛ Naresh Kumar Mehta¹؛ Dharmendra Kumar Meena^{* 2}؛ Gusheinzed Waikhom¹

¹College of Fisheries, Central Agricultural University, Lembucherra, Tripura-799210, India

²ICAR-Central Inland Fisheries Research Institute, Barrackpore, Kolkata, West Bengal-700120, India

چکیده

A class of drugs known as aromatase inhibitors can effectively inhibit aromatase, an enzyme that transforms androgens (male hormones) into estrogens (female hormones). These inhibitors are commonly used in medical treatments for hormone-sensitive conditions such as breast cancer in humans. In the context of fish, there has been some research on the use of aromatase inhibitors to alter the sexual development and secondary sexual characteristics of certain species. Aromatase inhibitors in fish may be used to manipulate sex ratios in aquaculture. In some fish species, the sexes of individuals are influenced by environmental variables, including temperature. By administering aromatase inhibitors, it is possible to suppress the production of estrogens and bias the sex ratio towards males. This can be desirable in certain aquaculture operations where males are preferred, such as for increased growth rates or reduced aggression. It is important to highlight that the use of hormone manipulation techniques in fish farming is subject to regulations and restrictions, as the potential environmental impacts and welfare considerations need to be carefully evaluated. The use of any pharmaceutical product in aquaculture requires rigorous testing and approval processes to ensure its safety and efficacy. This review discusses the multifaceted use of aromatase inhibitors in the manipulation of sex ratios in aquaculture, while emphasizing the imperative need for the systematic evaluation of environmental impacts and ethical considerations associated with this practice, and compliance with regulatory frameworks governing their implementation.

کلیدواژه‌ها

Fish؛ Anastrozole؛ Letrozole؛ Fadrozole؛ Exemestane؛ Masculinization