Exploring gastropods in drug discovery: a review of their bioactive compounds and pharmacological applications

International Aquatic Research

مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 26 مهر 1404   

نوع مقاله: Review

شناسه دیجیتال (DOI): 10.22034/iar.2025.2009493.1907

نویسندگان

Bhagyashree Mohanty¹؛ Sanghamitra Mishra^{* 2}

¹PhD Scholar, Department of Critical Care Medicine, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, K8, Kalinga Nagar, Bhubaneswar-751003, Odisha, India

²Dean and Professor, Department of Critical Care Medicine, Institute of Medical Sciences and Sum Hospital, Siksha ‘O’ Anusandhan Deemed to be University, K8, Kalinga Nagar, Bhubaneswar-751003, Odisha, India

چکیده

Mollusc species are an abundant source of secondary metabolites with numerous biological activities. Approximately eighty percent of mollusks are gastropods, which are used in various ways, including as food and traditional medicine, due to their high protein content. The use of various gastropods has grown rapidly in the last decades, particularly in the pharmaceutical, nutraceutical, and cosmetic products industries. This review focuses on the various bioactive compounds derived from gastropods and their corresponding biological activities. A list of essential factors for discovering and developing novel therapeutic drugs has also been discussed, along with a roadmap for further research on marine-derived products. This review provides a detailed discussion of the various metabolites isolated from different gastropod species, including 40 bioactive compounds and their reported biological activities. However, we aim to analyze the evidence for the traditional use of gastropods in controlling various clinical problems. This study suggests that isolated bioactive compounds are valid leads for medical biotechnologists and pharmaceutical chemists to design novel drug molecules.

کلیدواژه‌ها

Bioactive compounds؛ Gastropods؛ Biological activities؛ Natural product؛ Pharmaceutical