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. (1391). One-pot synthesis of Benzimidazole derivatives under microwave Irradiation and solvent-free condition. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1(2), 111-114.
. "One-pot synthesis of Benzimidazole derivatives under microwave Irradiation and solvent-free condition". نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1, 2, 1391, 111-114.
. (1391). 'One-pot synthesis of Benzimidazole derivatives under microwave Irradiation and solvent-free condition', نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1(2), pp. 111-114.
. One-pot synthesis of Benzimidazole derivatives under microwave Irradiation and solvent-free condition. نشریه علمی پژوهشی دانشگاه آزاد اسلامی, 1391; 1(2): 111-114.

One-pot synthesis of Benzimidazole derivatives under microwave Irradiation and solvent-free condition

Journal of Pharmaceutical & Health Sciences
مقاله 15، دوره 1، شماره 2، خرداد 2013، صفحه 111-114    اصل مقاله (292.2 K)
نوع مقاله: Original Article
چکیده
A simple, fast, efficient and environmentally friendly method for synthesis of benzimidazole and its 2-alkyl, aryl and heteroaryl substituted derivatives was developed using zeolite HY. Two component cyclolcondensation of 1,2-phenylenediamine (o-phenylenediamine) and commercially available carboxylic acids catalyzed by zeolite HY without any solvent, under microwave irradiation led to formation of 1H-benzimidazole and 2-substituted derivatives in high yields and purity. The similar reaction was not applicable to the preparation of benzimidazole and its 2-alkyl, aryl and heteroaryl substituted derivatives. All the synthesized compounds were characterized by 1H-NMR, IR, Mass and CHNS analysis.
کلیدواژه‌ها
Benzimidazole؛ zeolite HY؛ Microwave irradiation؛ Solvent-free
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