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One-Pot Synthesis of Phenytoin Analogs in Solvent free Conditions Via the Use of Pestle/ Mortar | ||
Journal of Chemical Reactivity and Synthesis | ||
مقاله 3، دوره 2، شماره 3، مرداد 2012، صفحه 20-27 اصل مقاله (385.77 K) | ||
نوع مقاله: Research Article | ||
نویسندگان | ||
Alireza Kiasat* ؛ Maryam Nikmanesh | ||
Department of Chemistry , Shahid Chamran University , Ahwaz , Iran | ||
چکیده | ||
phenytoine derivatives were synthesized , via the pinacol condensation with the reaction of 1,3- diphenyl- propane- 1,3- dione (benzyl) analogs with urea or thiourea in presence of slica gel and solid KOH as Solid phase catalyst in the mortar / pestle at room temperatures. The reaction was completed at short reaction times (approximately 15min) and pure products were obtained with high yields (81-94%). | ||
کلیدواژهها | ||
Phenytoin؛ Green Chemistry؛ solvent free؛ Synthesis؛ Grinding | ||
آمار تعداد مشاهده مقاله: 335 تعداد دریافت فایل اصل مقاله: 746 |