Biginelli Synthesis and Theoritical Study of Dihydropyrimidinone Compounds

Journal of Chemical Reactivity and Synthesis

مقاله 4، دوره 2، شماره 3، مرداد 2012، صفحه 28-34   

نوع مقاله: Research Article

نویسندگان

Mohammad Hosein Farjam^{* 1}؛ Ramin Rezaei²

¹Department of Chemistry , Firoozabad Branch, Islamic Azad University,Firoozabad, Iran

²Department of Chemistry , Firoozabad Branch, Islamic Azad University, Firoozabad, Iran

چکیده

An effective one-pot synthesis of dihydropyrimidinonoes in solvent free conditions using CuCl₂ as an inexpensive and readily available reagent through Biginelli condensation reaction of aldehyde derivatives, 1,3-dicarbonyl compounds and urea is described. Excellent yields, short reaction times for formation of the products and simple work-up are attractive features of this green protocol.

کلیدواژه‌ها

Biginelli reaction؛ Dihydropyrimidinones؛ One-pot؛ Solvent-free