Uranyle Complexes: synthesis, evaluation of biological activity

Journal of Chemical Reactivity and Synthesis

مقاله 5، دوره 4، شماره 1، شهریور 2014، صفحه 1-11   

نوع مقاله: Research Article

نویسندگان

Shahriar Ghammamy^{* 1}؛ Rozita Hosseinzadeh Khezri²؛ Zahra Amini²؛ Monir Al-sadat Mirrahimi²؛ Masoud Soleimani³؛ Saeid Kaviani³

¹Department of Chemistry, Faculty of Science, Imam Khomeini International University,Ghazvin, Iran

²Department of Chemistry, Faculty of Science, Imam Khomeini International University, Ghazvin, Iran

³Department of Hematology, Faculty of Medicine, Tarbiat Modarres University, P.O. Box, Tehran, Iran

چکیده

In this research, some of the inorganic complexes of uranyl with N- donor ligands
were synthesized. Complexes were characteriezed by FT-IR and UV spectra, ¹HNMR,
¹³CNMR and some physical properties. The uranyl unit (UO2) is composed of a center of
uranium atom with the charge (+6) and two oxygen atom by forming two U=O double bonds.
The structure is linear (O=U=O, 180) and usually stable. So other ligands often coordinate to
the U atom in the plane perpendicularly to the O=U=O axis. The antitumor activity of some of
ligand and their complexes against a panel of human tumor cell lines (HT29: Haman colon
adenocarcinoma cell line T47D: human breast adenocarcinoma cell line) were determined by
MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay. These data
suggest that some of these compounds provide good models for the further design of potent
antitumor compounds.

کلیدواژه‌ها

Inorganic؛ Uranyl complex-donor ligands؛ Schiff bases؛ Anticancer Activity

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