Evaluation of antibacterial effect of Myrtus communis against Acinetobacter baumannii clinical strains

Journal of Pharmaceutical & Health Sciences

مقاله 7، دوره 4، شماره 2، آذر 2016، صفحه 149-155   

نوع مقاله: Original Article

نویسندگان

Venous Akhavan¹؛ Mehdi Goudarzi^{* 2}؛ Faraz Mojab³

¹Department of Microbiology, Islamic Azad University of Pharmaceutical science (IAUPS),Tehran,Iran

²Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

³Department of Pharmaceutical Sciences Research Center ,Shahid Beheshti University of Medical Sciences, Tehran, Iran

چکیده

Because of inappropriate use of antibiotics and prevalence of resistant bacteria, there is urgent
need for antibacterial drugs that have fewer side effects than antibiotics. Myrtus communis is a
medicinal plant which had many uses in traditional medicine. In this study, ethanol leave extract
of this plant is tested on Acinetobacter baumannii. In the case of antimicrobial evaluation of
plants, one of the effecting factors on effectiveness of the microbial inhibition is extraction
techniques. In the presents study, the antibacterial activity of the Ethanol, Methanol, and
Ethyl acetate extracts of M. communis plant was evaluated at seven different concentrations
by broth microdilution method. The results of this study showed that the antimicrobial effect
of M. communis extract is concentration dependent. Different extracts were obtained by the
maceration method. Extracts of the plant exhibited antibacterial activity at varied levels against
A. baumannii. Obtained results from our antibacterial experiments showed that all extracts have
anti-bacterial activity against tested bacterial isolates According to the results, the ethyl acetate
extracted fraction showed the highest level of activity at a MIC 400 mg/ml for A. baumannii.
The results of this study indicate that, different extracts had growth inhibitory effect on A.
baumannii. Therefore this plant has the potential to be evaluated as an alternative or adjunct to
antibiotics to treat Acinetobacter infections.

کلیدواژه‌ها

Myrtus communis؛ Acinetobacter baumannii؛ Antibacterial؛ Clinical strains