Determination of Acetaminophen Via TiO2/MWCNT Modified Electrode

Journal of Nanoanalysis

مقاله 7، دوره 4، شماره 2، شهریور 2017، صفحه 142-149   

نوع مقاله: Original Research Paper

شناسه دیجیتال (DOI): 10.22034/jna.2017.02.007

نویسندگان

Ali Asghar Pasban¹؛ Elham Hossein Nia²؛ Masoumeh Piryaei^{* 3}

¹Refining Technology Development Division, Research Institute of Petroleum Industry, Tehran, Iran

²Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran

³Department of Biology, Faculty of Science, Payam Nour University, Tehran, Iran

چکیده

Electrochemical behaviour of acetaminophen at the multi wall carbon nanotubes/titanium dioxide (MWCNT/TiO2) composite film modified glassy carbon electrode (GCE) via solvent casting method was studied. It is shown that the MWCNT/TiO2/GCE exhibits remarkable improvement in analytical response as compared to other electrodes. Comparing the responses of the MWCNT/TiO2/GCE with that obtained at the unmodified glassy carbon electrode, the peak currents were enhanced significantly by 8.5 folds (oxidation peak) and 11.0 folds (reduction peak), which showed stable response with enhanced selectivity and sensitivity. A linear calibration plot having a correlation coefficient of 0.991 was obtained in the concentration range of 0.01-0.12 mM acetaminophen. The detection limit for the detection of acetaminophen was calculated as 11.77 μM based on 3 σ/m. The method was applied in the determination of acetaminophen in commercial tablets. The recoveries of the composite modified electrode obtained were 95.2 and 96.2% for five determinations.

کلیدواژه‌ها

Multi wall carbon nanotubes؛ Titanium dioxide nanoparticles؛ Composite؛ Acetaminophen؛ Cyclic voltammetry

مراجع

1. M. Kartal, J. Pharm. Biomed. Anal., 26, 857 (2001).

2. Sirajuddin, A.R. Khaskheli, A. Shah, M.I. Bhanger, A. Niaz and S. Mahesar, Spectrochim. Acta, 68A, 747 (2007).

3. A. Criado, S. Cárdenas, M. Gallego and M. Valcárcel, Analyst, 125, 1179 (2000).

4. S. Zhao, W. Bai, H. Yuan and D. Xiao, Anal. Chim. Acta, 559, 195 (2006).

5. S.J.R. Prabakar and S.S. Narayanan, Talanta, 72, 1818 (2007).

6. M. Knochen, J. Giglio and B.F. Reis, J. Pharm. Biomed. Anal., 33, 191 (2003).

7. P. Fanjul-Bolado, P.J. Lamas-Ardisana, D. Hernández- Santos and A. Costa-García, Anal. Chim. Acta, 638, 133 (2009).

8. S. M. Mostafavi, A. Rouhollahi, M. Adibi, M. Piryaei and F. Pashaee, Asian J. Chem, 23 (12), (2011)

9. B.C. Lourenc¸, R.A. Medeiros, R.C. Rocha-Filho, L.H. Mazo and O. Fatibello-Filho, Talanta, 78, 748 (2009).

10. C. Li, G. Zhan, Q. Yang and J. Lu, Bull. Korean Chem. Soc.,27, 11 (2006).

11. R.T. Kachoosangi, G.G. Wildgoose and R.G. Compton, Anal. Chim. Acta, 618, 54 (2003).

12. S. M. Mostafavi, A. Rouhollahi, M. Adibi, M. Piryaei and F.Pashaee, Asian J. Chem., 23 (12), (2011).

13. M. S. Khalili, M. Hajmalek and O. Zabihi, J. Nanoanalysis, 01 (01), 2014.