Phytochemical investigation and isolation of new compounds from the stems of Tinospora cordifolia Miers

Trends in Phytochemical Research

مقاله 6، دوره 1، شماره 2، شهریور 2017، صفحه 83-92   

نوع مقاله: Original Article

نویسندگان

Shahnaj Sultana^{1، 2}؛ Mohammed Ali^{* 1}؛ Mohammad Jameel³

¹Phytochemistry Research Laboratory, Faculty of Pharmacy, Jamia Hamdard, New Delhi- 110062, India

²College of Pharmacy, Jazan University, Jazan, Saudi Arabia

³1-F/O PHARMACY, DEPT OF PHARMACOGNOSY, JAMIA HAMDARD UNIVERSITY, NEW DELHI 2-Phytochemistry Research Laboratory, Faculty of Pharmacy, Jamia Hamdard, New Delhi- 110062, India

چکیده

Tinospora cordifolia (Willd.) Miers, (Menispermaceae), a glabrous, deciduous and trailing plant found in tropical India, China, Sri Lanka, Bangladesh and Myanmar. It is used to treat anemia, debility, diabetes, diarrhea, dysentery, dyspepsia, fevers, jaundice, rheumatism, urinary and skin diseases and snake bites. Its air-dried stem powder was exhaustively extracted with methanol. The concentrated methanolic extract was adsorbed on silica gel (60-120 mesh) for the preparation of a slurry. The dried slurry was chromatographed over silica gel column packed in petroleum ether. The column was eluted with petroleum ether, chloroform and methanol successively in order of increasing polarity to isolate a variety of new chemical constituents characterized as trans-cinnamoyl 2-n-hexanyl-7-methoxynaphthyl amide (2), trans-cinnamoyl 2-n- pentanyl- 6,7- dimethoxynaphthyl amide (3), trans-cinnamoyl 2-n-octanyl-7-methoxynaphthyl amide (4), β-D-arabinosyl-O-geranilan-10′-oate (5), 4,5,7-trimethoxy-2-naphthol-2-O-α-L- arabinofuranosyl-(2′→1′′)-O-α-L-arabinopyranosyl-2′′-O-pentane (6), 5,7-dimethoxy-2-naphthol-2-O-α-L-arabinopyranosyl-(2′→1′′)-α-L- arabinopyranosyl-2′′-O-decane (7) and 5-hydroxy-4''-methoxy-7- flavanoxy- (7→7'''')- β-O-labdan-1-en-3''''α,19''''-olide-18''''-oic acid (tinolabdenyl flavanone) (8) along with cetyl alcohol (1). The structures of all the isolated phytoconstituents have been established on the basis of spectral data analysis and chemical reactions.

کلیدواژه‌ها

Characterization؛ Chemical constituents؛ Isolation؛ Stems؛ Tinospora cordifolia

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Supplemental data.pdf

TCD2 C B Mass (y).pdf

TCD2CB 1H 13C NMR, 2D (y).pdf

TCD3A2 1H 13C NMR., 2D (y).pdf

TCD4 A2 mass (y)).pdf

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