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A Synthetic Approach for Evaluation of Cytosinediazonium Susceptibility | ||
Journal of Applied Chemical Research | ||
مقاله 15، دوره 11، شماره 3، مهر 2017، صفحه 84-96 اصل مقاله (302.72 K) | ||
نویسندگان | ||
Kamahldin Haghbeen* 1؛ Shima Rezaeian2؛ Mehdi Bakavoli2؛ Fatemeh Mirazizi3 | ||
1Faculty of Basic Sciences of Biotechnology, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran | ||
2Department of Chemistry, Ferdowsi University of Mashhad, Mashhad, Iran | ||
3Department of Chemistry, Islamic Azad University, Mashhad branch, Mashhad, Iran | ||
چکیده | ||
Reaction of a nucleobase with nitrosonium ion leads to its diazotization. Due to the instability, the nucleobase-diazonium assumingly falls in dediazotization and successive ring opening reactions. The resulting intermediate of the ring opening reaction is able to covalently cross-link the opposite strands of DNA. To examine this assumption for cytosine, some 4-amino-5-cyano pyrimidines were synthesized via [3+3] condensation of amidines with ethoxymethylenemalonitrile and successively converted to the corresponding 4-amino-5carboxyamido derivatives. These compounds were then exposed to nitrosonium ion under different conditions. Results of this study indicate that the diazonium of a 4-aminopyrimidine prefers deamination over the dediazotization. Therefore, the dediazotization and its successive ring-opening reactions of the pyrimidine cation would happen under some exceptional conditions which deserve to be explored in more detailed studies. In view of the cytosine chemistry and cytotoxicity of NO, the results are presented and discussed. | ||
کلیدواژهها | ||
4-Amino-pyrimidine؛ Cytosine؛ Deamination؛ Dediazotization؛ v-Triazine | ||
آمار تعداد مشاهده مقاله: 435 تعداد دریافت فایل اصل مقاله: 272 |