One-pot synthesis of triazolo[1,2-a]indazole-triones catalyzed by a novel magnetically and reusable green catalyst of Preyssler

Journal of Chemical Reactivity and Synthesis

مقاله 1، دوره 7، شماره 2، شهریور 2017، صفحه 1-70   

نوع مقاله: Research Article

نویسندگان

Maryam Akbari¹؛ Ali Javid^{* 1}؛ Farid Moeinpour²

¹Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

²Department of Chemistry, Bandar Abbas Branch, Islamic Azad University, Bandar Abbas, Iran

چکیده

An atom-efficient, eco-friendly, solvent-free, high yielding, multicomponent green strategy to synthesize triazolo[1,2-a]indazole-triones derivatives by the one-pot condensation of aldehyde, dimedone, and phenyl urazole under microwave Irradiationis presented. Reactions catalyzed by A novel nanomagnetic organic-inorganic hybrid catalyst (Fe@Si-Gu-Prs) was prepared by the chemical anchoring of Preyssler heteropolyacid (H₁₄[NaP₅W₃₀O₁₁₀]) onto the surface of modified Fe₃O₄ magnetic nanoparticles with guanidine-propyl-trimethoxysilane linker. A series of different substituted aromatic aldehydes including either electron-withdrawing or electron-donating groups used in this reaction participated well and gave the corresponding products in good to excellent yield. In this method, catalyst was isolated and reused several times, at least four times without significant loss of activity.

کلیدواژه‌ها

one-pot multicomponent reaction؛ Magnetic nanoparticles؛ Microwave irradiation؛ triazoloindazole؛ Preyssler